Abstract Number: PB2506
Meeting: ISTH 2020 Congress
Background: The severity of bleeding is usually not consistent with the platelet count in pregnancy with ITP. If the only criteria depend on platelet count, it can either cause overtreatment or delay the optimal treatment. The ITP International Working Group (IWG) recommended the use of ITP-specific bleeding assessment tool (ITP-BAT) in evaluating the risk of bleeding, but its clinical application was limited due to the long-term data collection. In order to shorten the evaluation time and improve the clinical operability, the 2016 version of ITP Bleeding Score Scale (ITP-2016) was recommended by Chinese specialists to be used in adult ITP. But it is unclear whether they are useful in pregnant women with ITP or not.
Aims: To compare the clinical practicability of two bleeding grading systems (BGS) in pregnancy with ITP.
Methods: 154 pregnancy with ITP were retrospectively analyzed with the two BGS. The correlation between the two BGS, and the relation among platelet counts, patients’ age and disease phase were respectively analyzed.
Results: There was no significant difference between different patients’ ages but statistically significant between the different phases (P=0.001; P=0.001). There was no significant difference between newly diagnosed and persistent group or chronic group. Statistical difference was found between persistent and chronic group (P=0.001, P=0.001). There was a negative correlation between bleeding grade and platelet counts (r=-0.436, P<0.001; r=-0.390, P<0.001), while the correlation between the two BGS was positive(r=0.921, P<0.001). The proportions of identical scores using the two BGS by two different physicians at the same time were 94.8% (P<0.001) and 93.5% (P<0.001) respectively. It takes less time to score with the ITP-2016(P=0.011)
Conclusions: Both BGS can be used as an effective tool for disease judgment, risk assessment and efficacy evaluation in pregnancy with ITP. The ITP-2016 takes less time and is more suitable for Chinese pregnancy with ITP.
To cite this abstract in AMA style:Huang MJ, Huang J, Zeng B, Chen P, Zhan R. Comparative Study of the Clinical Application of Two Bleeding Grading Systems for Pregnant Women with Immune Thrombocytopenia (ITP) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/comparative-study-of-the-clinical-application-of-two-bleeding-grading-systems-for-pregnant-women-with-immune-thrombocytopenia-itp/. Accessed January 26, 2022.
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