Abstract Number: PB0051
Meeting: ISTH 2020 Congress
Background: Cigarette smoking has assumed public health problem and is known to be the leading cause of preventable deaths in many countries of the world, 39% of these deaths is from cardiovascular disease. Eighty percent of the world 1.1 billion smokers live in developing countries.
Aims: The aim is to assess the effect of cigarette smoke on VWF, fibrinogen, factor VIII, VWF:CBA, APTT and PT levels of cigarette smokers in Calabar metropolis.
Methods: A cross sectional study involving 100 smokers (smoked between 1 and 30 years) and 80 non-smokers between the ages of 18-60 years. Ethical approval was obtained from the CRS MOH, Informed consent and a questionnaire from the studied participants. Blood samples was collected into K2EDTA bottle for VWF, VWF:CBA, FV VIII and fibrinogen, carried out with ELISA kit (Bioassay Technology laboratory, Shangai, China) and trisodium citrate for the assay of APTT and PT (Technochlone Diagnostic, Vienna, Austria), stored at -80C until ready to assay. The data were analysed using SPSS version 22 and MS excel.
Results: Fibrinogen (FIB) (2.39 g/L) was significantly higher as Von Willibrand Factor (VWF) and factor VIII (FVIII), (29.53 ng/ml and 30.40 mg/dl) dropped significantly in the smokers when compared to the non-smokers (P< 0.05). Whereas VWF:CBA, PT and APTT were not significant (P>0.05). FIB showed a significant decrease in 18-25 years (1.98g/L) when compared with 26-40 years (2.85g/L) P< 0.05, other parameters were not significant. There was a mild positive and negative correlation between VWF and FVIII (r=0.145, P< 0.05) and FVIII and APTT
(r=0.214, P< 0.05) respectively.
Conclusions: It can therefore be deduced that in smokers, there is a slight raise and dropped in FIB, VWF and FVII, which show a possibility of predisposing smokers to CVD. It will also help in the proper management of clinical conditions arising from cigarette smoking.
|Parameters/unit||Smokers (test) n=100||Non-Smokers (control) n=80||P value||Remark|
[Table 1: Mean ± SD of the haemostatic parameters of smokers when compared with non-smokers]
|Parameters/units||Group1 (18-25years) n=45||Group 11 (26-40years) n=45||Group 111(41-60years) n=10||F value||P value||Remark|
[Table 2: Mean ± SD of the haemostatic parameters of smokers based on the effect of age *Significantly different from Group 1 at P>0.05 S = Significant]
To cite this abstract in AMA style:Okpokam DC, Asuquo JI, Akpotuzor JO. Comparison and Association of Fibrinogen, von Willibrand Factor and Factor VIII Levels with Risk of Cardiovascular Disease in Cigarette Smokers Residing in Calabar Metropolis, Nigeria [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/comparison-and-association-of-fibrinogen-von-willibrand-factor-and-factor-viii-levels-with-risk-of-cardiovascular-disease-in-cigarette-smokers-residing-in-calabar-metropolis-nigeria/. Accessed January 28, 2022.
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