Abstract Number: PB1254
Meeting: ISTH 2020 Congress
Background: The bleeding time test, one of the tests used in evaluating platelet function, is difficult to perform, standardize and interpret in children.
Aims: To evaluate the sensitivity, specificity and efficiency of bleeding time test and PFA-200 in a series of pediatric cases with platelet dysfunction condition.
Methods: This prospective study was conducted at King Chulalongkorn Memorial Hospital (KCMH) during 2017-2019. Children, age ranging from 6 months to 18 years, were sent to undergo bleeding time together with other routine blood test. The authors used the residual sample, about 1.6 ml, to perform PFA-200. Ninety-seven children (51 of them females, mean age 9.14 ± 4.35 years) were enrolled into this study. The subjects were divided into 2 groups: platelet dysfunction group and normal platelet function group. All subjects were sent to undergo bleeding time and PFA-200. Subjects with congenital platelet disorder, including von Willebrand disease and Glanzmann´s thrombasthenia, and those who are Aspirin users represent the platelet dysfunction group. All of the patients in this group were confirmed to have platelet dysfunction by the gold standard test, platelet aggregation test.
Results: Use of PFA-200 offered 81.3% sensitivity and 95.9% specificity for detection of qualitative platelet abnormalities, whereas bleeding time testing showed 33.3% and 93.9% respectively.
Conclusions: The PFA-200 is a more efficient test; it, therefore, can replace the bleeding time test as a component of the laboratory evaluation of children with platelet dysfunction.
To cite this abstract in AMA style:Srichumpuang C, Sosothikul D. Comparison between Bleeding Time and PFA-200 to Evaluate Platelet Function Disorder in Children [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/comparison-between-bleeding-time-and-pfa-200-to-evaluate-platelet-function-disorder-in-children/. Accessed May 16, 2021.
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