Abstract Number: PB0368
Meeting: ISTH 2021 Congress
Background: Prothrombin time (PT) is essential in the routine hemostasis panel. To ensure proper patient medical care continuity, but also to allow the test to be available whatever the laboratory structure and organization, demonstration of consistency of results between semi-automated and automated test application is compulsory.
Aims: The objective of this study was to show the correlation and agreement of PT/INR results with STA-NeoPTimal when determined on STA-R Max analyzer or with the newly developed application on STart-Max semi-automated system.
Methods: A total of 144 samples was tested in parallel with one batch of STA-NeoPTimal on STA-R Max and STart Max (all Stago, Asnières-sur-Seine, France). The sample set covered the measuring range from 10 to 90 seconds in PT sec and from 1 to 6 in INR. It consisted in 57 normal individual samples 64 samples from patients under VKA, 5 samples from patients with extrinsic factor pathway deficiency, 7 patients with multiple acquired deficiency and 11 samples from patients under heparin treatment.
The ISI used for INR determination were the ones provided by the while the mean normal prothrombin times (MNPT) were the one determined locally on 20 normal samples.
Results: The MNPT was of 13.6 seconds on STA-R Max and 14.8 seconds on STart Max.
No outlier was detected during the analysis of the comparison data. Passing-Bablok regression was performed to evaluate correlations. Slope, intercept and Pearson correlation coefficients of those regressions are displayed in table 1.
|STart Max vs STA-R Max||Passing-Bablok regression equation
y = ax + b
|Pearson correlation coefficient (r)|
|Slope (a)||Intercept (b)|
Conclusions: The correlation along the measuring range was excellent. Even if PT clotting times were slightly prolonged and INR values slightly lower on STart Max vs STA-R Max results, consistency of results was proven. PT/INR determination with STA-NeoPTimal can be safely measured either using its semi-automated or automated methodologies These results open the door for an easier usage of STA-NeoPTimal in any type of laboratory.
To cite this abstract in AMA style:Savigny S, Depasse F, Veyradier A. Comparison of PT/INR Assessment with STA-NeoPTimal on an Automated and Semi-automated Test Platform [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/comparison-of-pt-inr-assessment-with-sta-neoptimal-on-an-automated-and-semi-automated-test-platform/. Accessed November 29, 2021.
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