Abstract Number: PB2326
Meeting: ISTH 2020 Congress
Background: Plasma D-dimer levels in healthy subjects have been associated with increased risk of incident VTE and coronary heart disease. Intrinsic D-dimer has therefore been proposed as a potential marker of inherent hypercoagulability. However, whether high intrinsic D-dimer levels correlate with D-dimer levels in response to a venous thrombotic event has not been investigated.
Aims: To explore the correlation between intrinsic D-dimer and D-dimer at the time of VTE diagnosis.
Methods: Participants were recruited from the fourth survey of the Tromsø study, conducted in 1994-1995, and followed until 1 September 2007. During the follow-up, 198 cancer-free patients with a first life-time VTE were identified and included in the present study. Intrinsic D-dimer was analyzed from stored plasma samples collected at inclusion (1994/95), and D-dimer levels at the time of VTE diagnosis were assessed as a part of the diagnostic work-up of suspected VTE. The Pearson’s correlation coefficient was used to test for correlation between intrinsic D-dimer and D-dimer at the time of VTE diagnosis.
Results: Intrinsic D-dimer and D-dimer measured at time of VTE diagnosis were positively correlated (r = 0.18, p = 0.001). Further stratification by sex revealed that the correlation was stronger in women (r = 0.28, p = 0.004) than in men (r = 0.09, p = 0.381). The mean time between the measurements of intrinsic and diagnostic D-dimer was 7.4 years in women and 7.8 years in men. The estimated correlation was strongest during the first year after the intrinsic measurement and decreased thereafter.
Conclusions: Our findings suggest a positive correlation between intrinsic D-dimer and D-dimer at the time of VTE diagnosis in women but not in men, suggesting that inherent hypercoagulability partly explain plasma d-dimer levels at VTE diagnosis.
To cite this abstract in AMA style:Rinde FB, Hansen E-, Morelli V, Hansen J-, Brækkan SK. Correlation between Intrinsic D-Dimer Levels and D-Dimer Measured at First Venous Thromboembolism (VTE) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/correlation-between-intrinsic-d-dimer-levels-and-d-dimer-measured-at-first-venous-thromboembolism-vte/. Accessed October 1, 2023.
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