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Current Data About Arterial Thrombotic Events in Cerebrovascular Circulation Caused by Sticky Platelet Syndrome in the National Registry of Thrombophilic States in Slovak Republic

1Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin University Hospital, National Centre of Haemostasis and Thrombosis, Department of Haematology and Transfusiology, Martin, Slovakia, 2Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin University Hospital, Martin, Slovakia, National Centre of Haemostasis and Thrombosis, Department of Haematology and Transfusiology, Martin, Slovakia, 3Comenius University in Bratislava, Department of Clinical Biochemistry, Martin, Slovakia

Abstract Number: PB1513

Meeting: ISTH 2020 Congress

Theme: Platelet Disorders and von Willebrand Disease » Platelet Function Disorders, Hereditary

Background: Sticky platelet syndrome (SPS) is a prothrombotic disorder of haemostasis with familial occurrence characterized by hyperaggregability of platelets in response to low concentrations of adenosine diphosphate (ADP) or epinephrine (EPI) or both and is associated with arterial and venous thrombosis. SPS can affect people in all age categories. Because of the seriousness of the symptoms and the risk of disability of young people, it is necessary to take it into account in the differential diagnosis of the underlying cause of unexplained thrombotic events. Transient ischemic attack (TIA) and ischaemic stroke (IS) are one of the most common clinical manifestations of the SPS.

Aims: The aim of this study is to provide insight into the background of the thrombotic events caused by SPS, especially with a focus on thrombotic events in cerebrovascular circulation.

Methods: The authors analyzed the presence of SPS in patients with history of thrombotic episodes and described individual types of SPS and further characteristics in patients after TIA or IS.

Results: In this comprehensive study, the authors revealed the influence of the SPS on the development of thrombosis. In the selected groups of individuals, they also assessed the different types of SPS.

Conclusions: SPS is a serious risk factor for development of thrombotic events and therefore we should take it into account in management of patients with unexplained cause of thrombosis.

Acknowledgement: The authors would like to thank the support of projects of the Agency for the Support of Research and Development (APVV) APVV-16-0020 and Comenius University Grants for Doctoral Students UK/269/2019.

To cite this abstract in AMA style:

Brunclikova M, Stanciakova L, Ivankova J, Skerenova M, Dobrotova M, Holly P, Simurda T, Kubisz P, Stasko J. Current Data About Arterial Thrombotic Events in Cerebrovascular Circulation Caused by Sticky Platelet Syndrome in the National Registry of Thrombophilic States in Slovak Republic [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/current-data-about-arterial-thrombotic-events-in-cerebrovascular-circulation-caused-by-sticky-platelet-syndrome-in-the-national-registry-of-thrombophilic-states-in-slovak-republic/. Accessed September 29, 2023.

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