Abstract Number: PB2135
Meeting: ISTH 2020 Congress
Background: Cancer associated thrombosis is a leading cause of morbidity and mortality in malignancy patients. It is multifactorial in origin, being related to type, site, stage as well as treatment of underlying malignancy. Prophylactic anticoagulation is often underutilized. Also, cost of LMWH and direct oral anticoagulants is a major barrier in developing countries.
Aims: To analyze the patient and disease related parameters in cancer associated thrombosis.
Methods: We did a retrospective analysis of all cancer associated thrombosis patients attending our thrombosis clinic between 2011-2015 at a tertiary level referral hospital based in North India. Patient demographics and disease related parameters were collected and analyzed.
Results: A total of 771 patients attended DVT clinic during study period, of which 64 were malignancy associated. Of these, 56% were female and 20% patients were bed ridden. Median age was 48.5 years with adenocarcinoma (48%) being the most common histological subtype, followed by squamous cell carcinoma (16%). Gynecological malignancies (20%) were the most common malignancies, followed by genitourinary (11%) and then CNS (9%) and gastrointestinal malignancies (7%). Most of the cases occurred during first year of diagnosis (51%), and only 14% occurred after 3 years. Most of the patients were on combination treatment, followed by surgical and chemotherapy based regimens. Lower limb thrombosis was most commonly seen (56%), abdominal and pulmonary thrombosis were seen in 5% each. Most of the patients were managed with LMWH and vitamin K antagonists (84.3%) and only 6.25% with LMWH alone.
Conclusions: Malignancy associated DVT is very common and presents an unmet need for prophylactic anticoagulation. Most of the cases occur early in disease course, and can be harbinger of relapse. Most cases involve lower limb veins, but pulmonary and abdominal veins may also be thrombosed. Early suspicion and prompt treatment can improve quality of life in such patients.
To cite this abstract in AMA style:Aggarwal M, Ramaswami A, Mahapatra M. Current Status on Non-hematological Cancer Associated Thrombosis at Tertiary Care Hospital in India [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/current-status-on-non-hematological-cancer-associated-thrombosis-at-tertiary-care-hospital-in-india/. Accessed September 21, 2023.
« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/current-status-on-non-hematological-cancer-associated-thrombosis-at-tertiary-care-hospital-in-india/