Abstract Number: PO0008
Meeting: ISTH 2022 Congress
Theme: COVID and Coagulation » COVID and Coagulation, Clinical
Background: Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2).This virus may predispose patients to venous thromboembolic [VTE] complications.
.Venous Thromboembolic Disease i.e. DVT and PE are distinct clinical entities but manifestation of the same disease. Pulmonary embolism is a complication of DVT. Coagulopathy include haemostatic abnormalities with increased levels of D-dimers. D-dimers are fibrinolytic products produced at the site of venous thrombosis
Aims: Our aim was to study the presence or absence of D-dimers in the blood of a patient with suspected Covid 19 diseases which could help in confirming or refuting the diagnosis.
Methods: Study done at tertiary hospital, Mumbai, India, 400 patients sample tested for D-Dimer, admitted with fever, RT-PCR positive and some also had other underlying clinical history..
By using STA-Liatest D-D plus kit analyzed quantitative on Stago Compact Max Instrument using latex enhanced immunoturbidimetric assay.
Results: N: 50 Normal [12.5 %] D- dimer normal .Covid test negative, all tested lab parameters normal.
N: 340 true positive [85 %] D-dimer positive. Covid positive patients
N: 08: false positive [2 %] D-Dimer False Positive .Patient Covid negative
N: 02 false negative [0.5 %]-D-Dimer false negative. Patient Covid positive
Sensitivity: 99.42 %, Specificity: 86.21 %
[ Normal Range of D-DIMER : < or =500 ng/mL ]
Conclusion(s): D-Dimer is increased in thrombotic events indicating fibrinolysis.. D-Dimer quantification with persistent elevation of D-Dimer gives clue of presence of DVT which can avail in diagnosing VTE
Key message:
.Early diagnosis and prompt treatment can prevent patients from critical complication of VTE disease
Chest CT to be considered in all patients suspected of having COVID-19 who have an indication for hospital admission Prophylactic-dose low-molecular-weight heparin to be initiated in all hospitalized patients with proven or suspected COVID-19 .
To cite this abstract in AMA style:
LOURENCO E, JAKHI A, THOMAS N, PANDEY A, SHEIKH D, KRIPLANI D, ANTIA D. D-dimer in SARS-CoV-2 ! its importance in diagnosis and treatment. [abstract]. https://abstracts.isth.org/abstract/d-dimer-in-sars-cov-2-its-importance-in-diagnosis-and-treatment/. Accessed October 1, 2023.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/d-dimer-in-sars-cov-2-its-importance-in-diagnosis-and-treatment/