Abstract Number: PO0008
Meeting: ISTH 2022 Congress
Background: Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2).This virus may predispose patients to venous thromboembolic [VTE] complications.
.Venous Thromboembolic Disease i.e. DVT and PE are distinct clinical entities but manifestation of the same disease. Pulmonary embolism is a complication of DVT. Coagulopathy include haemostatic abnormalities with increased levels of D-dimers. D-dimers are fibrinolytic products produced at the site of venous thrombosis
Aims: Our aim was to study the presence or absence of D-dimers in the blood of a patient with suspected Covid 19 diseases which could help in confirming or refuting the diagnosis.
Methods: Study done at tertiary hospital, Mumbai, India, 400 patients sample tested for D-Dimer, admitted with fever, RT-PCR positive and some also had other underlying clinical history..
By using STA-Liatest D-D plus kit analyzed quantitative on Stago Compact Max Instrument using latex enhanced immunoturbidimetric assay.
Results: N: 50 Normal [12.5 %] D- dimer normal .Covid test negative, all tested lab parameters normal.
N: 340 true positive [85 %] D-dimer positive. Covid positive patients
N: 08: false positive [2 %] D-Dimer False Positive .Patient Covid negative
N: 02 false negative [0.5 %]-D-Dimer false negative. Patient Covid positive
Sensitivity: 99.42 %, Specificity: 86.21 %
[ Normal Range of D-DIMER : < or =500 ng/mL ]
Conclusion(s): D-Dimer is increased in thrombotic events indicating fibrinolysis.. D-Dimer quantification with persistent elevation of D-Dimer gives clue of presence of DVT which can avail in diagnosing VTE
.Early diagnosis and prompt treatment can prevent patients from critical complication of VTE disease
Chest CT to be considered in all patients suspected of having COVID-19 who have an indication for hospital admission Prophylactic-dose low-molecular-weight heparin to be initiated in all hospitalized patients with proven or suspected COVID-19 .
To cite this abstract in AMA style:LOURENCO E, JAKHI A, THOMAS N, PANDEY A, SHEIKH D, KRIPLANI D, ANTIA D. D-dimer in SARS-CoV-2 ! its importance in diagnosis and treatment. [abstract]. https://abstracts.isth.org/abstract/d-dimer-in-sars-cov-2-its-importance-in-diagnosis-and-treatment/. Accessed October 1, 2023.
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