Abstract Number: PB2516
Meeting: ISTH 2020 Congress
Background: D-Dimers are products of fibrin degradatio.
Aims: We examinated D-dimer levels early and late postpartum to assess whether D-dimer levels have role to play in predicting adverse events postpartum.
Methods: Only healthy pregnanat woman were included in the study.
Results: 35 women participated in this study and 27 women returned for the late postpartum period. In the immediate postpartum period 34 0f35 (97%) women had D-dimer levels higher than the normal nonpregnant range (< 500 ng/ml). By 4-6 weeks postpartum, D-dimer had returned to non-pregnant normal levels in 70 % of women. There was a high variability in D-dimer levels in the early postpartum period: level ranged between 550-5700 ng/ml. In later postpartum period D-dimer level had decreased between 100- 900 ng/ml. D-dimers levels were significantly elevated among women who had cesarean section when comparated to women who had normal vaginal delivery (2500 ng/ml -1350 ng/ml).
Maternal age, BMI, maternal blood type, were not associated with D-Dimer levels.
None of the women who participated in our study have had any adverse events postpartum.
Conclusions: D-Dimer levels are elevated and highly variable in the immediate postpartum period. D-Dimer levels decrease subsequently and toward normal (< 500 ng/ml) by 4-5 weeks postpartum.
C- section delivery is a major factor increasing D-Dimer levels postpartum.Higher levels od d-Dimer may be considered normal for the postpartum period ranges and ranges may need to be adjusted for delivery method.
More studies are indicated to help assessif normal ranges for D-dimers in the postpartum period can be determined if the test is to serve a useful diagnostic purpose.
To cite this abstract in AMA style:Malinova T, Stambolieva D, Ortakovska S. D-Dimer Variability in the Postpartum Period [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/d-dimer-variability-in-the-postpartum-period/. Accessed March 3, 2021.
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