Background: Deconstruction, form of philosophical and literary analysis, derived mainly from work begun in the 1960s by the French philosopher Jacques Derrida. To “deconstruct” an opposition is to explore the tensions and contradictions between the hierarchical ordering assumed (and sometimes explicitly asserted) in the text and other aspects of the text’s meaning. The point of the deconstructive analysis is to restructure, or “displace,” the opposition, not simply to reverse it. Deconstruction’s influence widened to include a variety of other disciplines, such as medical practice.

Aims: To deconstruct the explicit representative model of APS (updated in Sydney).

Methods: This work is only referred to the called non-thrombotic obstetric APS and do not is applicable to other clear well established autoimmune diseases (LES, Rheumatoid Arthritis etc.). Material: The International Classification Criteria propose to define the APS and the use in the daily medical practice of the antiphospholipid antibodies (aPL). Method: In 1^st column we describe the traditional “scientific perspective of the classical APS”; in the 2^nd column the social widespread and real-world use of aPL and the 3^rd we propose what is needed to be deconstructed before new/future classifications of APS.    

Results: Deconstruction of traditional obstetric APS is needed. See Table.

Conclusions: APS has become a familiar concept and the truth for daily practice in women with pregnancies complications.  We propose an effort to open a new way of looking the APS at health care. We need to give a correct answer to women at reproductive age and not create false expectative when detecting aPL.  The scientific consensus of APS classification criteria contrasts with the real daily practice. After deconstruction of the APS a new reconstruction of this syndrome can open a clearer way for the diagnosis and treatment pregnancies complications.  

« Back to ISTH 2021 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/deconstructing-the-obstetric-antiphopholipid-syndrome-aps/