Abstract Number: PB0026
Meeting: ISTH 2022 Congress
Background: Increased levels of factor VIII (FVIII) have been associated with acute ischemic stroke(AIS), but its prognostic value remain controversial until now. That’s why FVIII testing during AIS, seems to be interested and also, can be useful for assessing the chances of recovery which is critical to optimize poststroke care.
Aims: To assess the prognostic value of factor VIII in the prediction excellent outcome.
Methods: The study was carried out on 46 adult patients with acute ischemic stroke. Blood samples were taken on admission, to measure FVIII activity. Neurological deficit of patients was determined according to modified Rankin scale (mRS). The end point of this study was excellent outcome at 30 days defined as mRS: (0 –1), during the follow-up period.
Results: On the admission, elevated levels of FVIII, were associated with severity of AIS according to mRS: mean and IQR values: mRS < 5: 127% (73 – 148%); mRS ≥ 5: 193% (125 – 245%), p = 0.042. Moreover, a positive moderate correlation was found between FVIII levels and mRS at 30 days of follow-up, with coefficient of Pearson (r = 0.600) and p < 0.0001. FVIII was significantly decreased in patients with excellent outcome (mRS: 0 – 1) comparing to the rest of patients, mean and IQR values: mRS ≤1: 98% (73 – 113%); mRS > 1: 171% (108 – 235%), p < 0.0001. Patients with factor VIII levels below 124% are more likely to have an excellent evolution30 days after AIS, with an Odds Ratio = 20 [CI: 3.72 – 107.65]; p < 0.0001; χ² = 15.97.
Conclusion(s): In patients with ischemic stroke, the decrease in factor VIII activity levels shows good prognosis value concording with excellent functional results at 30 days. These results may be useful both in clinical practice and in research but require validation by further studies.
To cite this abstract in AMA style:
El Horri M, Bemmoussat F, Messaoudi R, Moueden M, El Horri F, Benlaldj D, Khachaa I, Khitri G, Chikh Khelifa A, Smahi M, Benbouhadi K, Kebir K, Zatir S, Benmahdi L, BROUK H. Decreased Levels of Factor VIII During Acute Ischemic Stroke Predict Excellent Outcome Thirty Days After [abstract]. https://abstracts.isth.org/abstract/decreased-levels-of-factor-viii-during-acute-ischemic-stroke-predict-excellent-outcome-thirty-days-after/. Accessed March 21, 2024.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/decreased-levels-of-factor-viii-during-acute-ischemic-stroke-predict-excellent-outcome-thirty-days-after/