Background: Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing. Common features of these patients, like advanced stage, male gender and old age are risk factors of VTE. Intra-papillary and mucinous nonneoplastic cyst of the pancreas (IPMNP) are benign neoplasm due to the proliferation of the ductal epithelium. It is usualy diagnosed fortuitously.

Aims: To determine the link between IPMNP, a precancerous condition and DVT.

Methods: We report 3 cases of deep venous thrombosis (DVT) associated with IPMNP.

Results: Tow men and 1 woman with a mean age of 78 years (70, 83 and 81 years) were admitted for management of DVT of the lower limb treated with heparin then oral anti-coagulant drug during 12 months. The biological analysis were within the normal range. An abdominal CT scan revealed a pancreatic mass in all patients. A pancreatic magnetic resonance imaging showed a cystic lesions in cephalic body of the pancreas in 2 cases with other cystic lesions of caudal pancreas in the other case. Then, our patients were diagnosed with DVP associated with IPMNP. Only 1 patient developed pancreatic insufficiency. As the concern for malignant transformation to pancreatic cancer is great, a magnetic resonance imaging was underwent every 1 year in the 3 cases with no malignant transformation.

Conclusions: DVT can reveal a malignant and asymptomatic neoplasm. We describe 3 cases of thromboembolic event associated with a benign pancreatic tumor. Because the potential of IPMNPs for malignancy is high, which suggest a magnetic resonance imaging control every 12 months espacially when associated with DVT.

« Back to ISTH 2020 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/deep-venous-thrombosis-and-intraductal-papillary-and-mucinous-tumor-of-the-pancreas-about-3-cases/