Abstract Number: PB2144
Meeting: ISTH 2020 Congress
Background: Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing. Common features of these patients, like advanced stage, male gender and old age are risk factors of VTE. Intra-papillary and mucinous nonneoplastic cyst of the pancreas (IPMNP) are benign neoplasm due to the proliferation of the ductal epithelium. It is usualy diagnosed fortuitously.
Aims: To determine the link between IPMNP, a precancerous condition and DVT.
Methods: We report 3 cases of deep venous thrombosis (DVT) associated with IPMNP.
Results: Tow men and 1 woman with a mean age of 78 years (70, 83 and 81 years) were admitted for management of DVT of the lower limb treated with heparin then oral anti-coagulant drug during 12 months. The biological analysis were within the normal range. An abdominal CT scan revealed a pancreatic mass in all patients. A pancreatic magnetic resonance imaging showed a cystic lesions in cephalic body of the pancreas in 2 cases with other cystic lesions of caudal pancreas in the other case. Then, our patients were diagnosed with DVP associated with IPMNP. Only 1 patient developed pancreatic insufficiency. As the concern for malignant transformation to pancreatic cancer is great, a magnetic resonance imaging was underwent every 1 year in the 3 cases with no malignant transformation.
Conclusions: DVT can reveal a malignant and asymptomatic neoplasm. We describe 3 cases of thromboembolic event associated with a benign pancreatic tumor. Because the potential of IPMNPs for malignancy is high, which suggest a magnetic resonance imaging control every 12 months espacially when associated with DVT.
To cite this abstract in AMA style:Cherif Y, Ghariani R, Mrouki M, Derbal S, Ben Dahmen F, Abdallah M. Deep Venous Thrombosis and Intraductal Papillary and Mucinous Tumor of the Pancreas: about 3 Cases [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/deep-venous-thrombosis-and-intraductal-papillary-and-mucinous-tumor-of-the-pancreas-about-3-cases/. Accessed November 30, 2023.
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