Background: Older adults (more than 75 years) with acute venous thromboembolism (VTE) are thought to have different demographic characteristics and profile of risk factors compared to the group of patients between the ages of 40 and 75, which could be associated with different clinical outcomes.

Aims: Assess demographic profile, risk factors, and clinical outcomes such as VTE recurrence, major bleeding, clinically relevant non major bleeding (CRNMB) and survival in older adults treated with anticoagulation for acute VTE.

Methods: Consecutive patients treated at the Mayo Clinic VTE Registry between March 1, 2013 and November 30, 2019 for acute VTE were followed prospectively. Patient outcomes were assessed in person, by mailed questionnaire, or by a scripted phone interview.

Results: During the study period, there were 242 older adults with age >75 years and 1224 with age 40-75 years. Older adults had less VTE provoked by hormonal therapy/pregnancy or by other provoking factors (e.g. reduced mobility from recent travel or prolonged hospitalization, acute infections or catheter insertion) compared to the patients with the age of 40-75 years (Table 1). Older adults had significantly worse survival and higher major bleeding. VTE recurrence and CRNMB rates did not differ by age group (Table 2).

Conclusions: Older adults with acute VTE have similar demographic profile but have significantly higher major bleeding rate compared to the group of patients between 40 and 75 years of age. Survival is lower as expected in the older age group.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/demographics-and-clinical-outcomes-of-older-adults-treated-for-acute-venous-thromboembolism/