Abstract Number: PB2292
Meeting: ISTH 2020 Congress
Background: DVT is the formation of thrombi in the deep veins, most commonly the large veins of the legs or pelvis. Numerous efforts have been made to identify reliable and predictive biomarkers to detect the early signs of deep vein thrombosis. Circulating microRNAs (miRNAs) are stably present in the plasma. Their diagnostic function has been investigated in many diseases.
Aims: The aims of present study were to assess the diagnostic ability of plasma miRNA-126 in DVT.
Methods: 47 DVT patients, 36 healthy controls were enrolled in this study. The TaqMan miRNA microarray was used to identify dysregulated miRNAs in the plasma of APE patients. The TaqMan-based miRNA quantitative real-time reverse transcription polymerase chain reactions were used to validate the dysregulated miRNAs. The receiver-operator characteristic (ROC) curve analysis was conducted to evaluate the diagnostic accuracy of the miRNA-126 identified as the candidate biomarker.
Results: Plasma miRNA-126 level was significantly higher in the DVT patients than in the normal controls. The ROC curve showed that plasma miR-126 was a specific diagnostic predictor of DVT with an area under the curve of 0.782 (95% confidence interval, P < 0.01).
Conclusions: Our findings indicated that plasma miR-126 is associated with DVT and it could be an important biomarker for the diagnosis of DVT.
To cite this abstract in AMA style:Bai X, Su J, Zhao Y, Zhang W, Ruan C. Detection of MicroRNA-126 as a Plasma Biomarker for Diagnosis of DVT [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/detection-of-microrna-126-as-a-plasma-biomarker-for-diagnosis-of-dvt/. Accessed January 23, 2022.
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