Abstract Number: PB2100
Meeting: ISTH 2020 Congress
Background: Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in patients with cancer. Cancer is the leading cause of death in Cuba, in the age group between 15 and 65 years. In 2018, 1 603 deaths were due to hematologic malignancies (HM). Although several well validated scores stratify the risk for VTE in solid tumors, HM are underrepresented in these models.
Aims: To design a predictive score for VTE risk stratification in patients with HM.
Methods: A case-control study was carried out at the University Hospital Arnaldo Milián Castro in Santa Clara, Cuba from January 2016 to January 2019. The study population was 285 patients (case group: 94 patients with VTE / control group: 191 without VTE), hospitalized with a diagnosis of HM. For the univariate analysis chi-square test was applied, Odds Ratio for risk estimation, Cramer´s V for strength of association. The logistic regression and the ROC curve were applied in the multivariate analysis. Power for each predictor were determined by their associated coefficients. Informed consent was obtained and the study was approved by a medical ethics committee complying with the Declaration of Helsinki.
Results: The predictive score for VTE
|Factors||Coefficient||Points||Wald||p||OR||CI 95% to OR|
|Use of thrombogenic drugs||1.59||2||13.51||0.0002||4.90||2.10-11.43|
[Predictive factors of VTE according to logistic regression analysis.]
includes 5 predictive factors: hypercholesterolemia, tumoral activity, bedding, use of thrombogenic drugs and diabetes mellitus. Patients obtaining four points or more was defined as high risk, which corresponded with the 75th percentile of the empirical distribution of the prognostic score values. Those who reached less than four points was defined as low risk. The score correctly classified 81.1% of the patients, with positive and negative predictive values of 78.8% and 82.2% respectively. The sensitivity was 59.5 % and the specificity of a 92.1%
|Predictive scores||Observed thrombotic events|
|High risk (>=4 points)||56||15||71|
|Low risk (<4 points)||38||176||214|
|Positive predictive value (%)||78.87||68.67-89.07|
|Negative predictive value (%)||82.84||76.87-87.6|
[Evaluation of the VTE predictive score according to basic performance indicators.]
Conclusions: The VTE risk score represented a specific and effective tool for the prediction of VTE in the patient with HM.
To cite this abstract in AMA style:López Sacerio A, Rendón Peralta S, Barreto Fiu E, Alvarez Basulto N, Acosta Alvarez M. Development of Predictive Score for Venous Thromboembolism in Hematologic Malignancies [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/development-of-predictive-score-for-venous-thromboembolism-in-hematologic-malignancies/. Accessed November 30, 2021.
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