Abstract Number: PB0030
Meeting: ISTH 2020 Congress
Background: Intracranial atherosclerosis is one of the most common cause of stroke worldwide.There is strong association exists between diabetes and cardiovascular disease. Coronary artery disease due to atherosclerosis is the leading cause of death in diabetic patients and imposes significant burden on the patients and the society. Evaluation and prevention of intracranial atherosclerosis is important.
Aims: Therefore, in this study, we are exploring the risk of intracranial atherosclerosis due to diabetes mellitus.
Methods: The literature search was performed in databases including PubMed and Embase from inception to December 2019. Two investigators independently retrieved the literature, extracted the data and assess the study quality using the Newcastle-Ottawa scale. The primary outcome was to assess the association between diabetes mellitus and risk of intracranial atherosclerosis. The secondary outcomes include subgroup analysis based on ethnicity, study populations, and co-morbidities. Review Manager version 5.3 was used for the statistical analysis.
Results: Finally, twelve studies qualified for quantitative analysis with a total of 18067 patients. Included studies were of high quality. A non-significantly higher association was observed for the association between diabetes mellitus and risk of intracranial atherosclerosis with a pooled relative risk (RR) of 1.98 (95% CI: 1.67 – 2.30), p =0.07 as compared to patients without diabetes mellitus. A significant association was observed among community-dwelling diabetes mellitus patients with a RR of 1.95 (95% CI: 1.53 – 2.50), p = 0.01.Subgroup analysis based on stroke patients also revealed no significant association with a pooled risk ratio of 2.14 (95% CI: 1.74 – 2.52), p = 0.96.
Conclusions: Diabetes mellitus might be a risk factor for intracranial atherosclerosis. A significant association was observed in community-dwelling people with diabetes. Further relevant research is needed to make the evidence transparent.
To cite this abstract in AMA style:Hussain S, Najmi AK. Diabetes Mellitus and Risk of Intracranial Atherosclerosis: A Meta-Analysis Using Real-World Evidence [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/diabetes-mellitus-and-risk-of-intracranial-atherosclerosis-a-meta-analysis-using-real-world-evidence/. Accessed November 29, 2023.
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