Abstract Number: PB0824
Meeting: ISTH 2020 Congress
Background: Currently, the life expectancy of people with haemophilia (PWH) is similar to the general population. The new substitute therapies and in particular extended half-life factors allow to improve the quality of life with a physical activity in accordance with the WHO recommendations. However, the risk of traumatic and subclinical hemarthros remains present. The treatment, the evolutionary control of acute hemarthrosis and the prevention of degenerative processes: arthropathy, remain important in the health control of PWH.
Aims: Perform an analysis of the current status of the most affected joints (elbows, knees and ankles) in PWH using unified clinical and ultrasound criteria, in addition to carry out a 18 months-follow up to assess bleeding incidents, physical function and quality of life.
Methods: Observational, longitudinal, prospective, multicentre study (NO-EPA classification). The subjects will attend a total of two visits to the referral hospital (baseline and 18-months follow up). The following data will be collected: clinical and demographic data, clinical assessment (Haemophilia Joint Health Score, HJHS), ultrasound assessment, self-perceived functional abilities (Haemophilia Activity List (HAL) and Pediatric HAL (PedHAL), Quality of Life (A36 hemophilia-QoL).
Results: At this moment, as preliminary evaluation, we have n=40 PWH, however our objective is to reach n=150 subjects. Through the different clinical evaluation and the ultrasound we can observe how both children and adults, despite treatment, continue to have some subclinical bleeding, affecting their joint health, decreasing their physical activity and worsening their quality of life
(Table 1 and 2).
Conclusions: Using unified clinical and base ultrasound criteria to control health joint evolution in PWH will allow us the early detection of subclinical bleeding and the adoption of medical and physiotherapy tailored measures to prevent joint deterioration.
|Children (n=4)||Adults (n=36)|
|Type of haemophilia (A/B)||4/0||35/1|
|Replacement treatment (prophylaxis/on demand)||4/0||28/8|
[Clinical and demographic data (ABJR: Annual Bleeding Joint Rate).]
|Children (n=4)||Adults (n=36)|
|Effusion Ultrasound (RE/LE/RK/LK/RA/LA)||0/0/0/1/0/0||0/0/8/5/2/2|
|Synovitis Ultrasound (RE/LE/RK/LK/RA/LA)||0/0/0/0/0/0||10/13/11/11/17/17|
[Questionnaire and ultrasound data (RE: Right Elbow; LE: Left Elbow; RK: Right Knee; LK: Left Knee; RA: Right Ankle; LA: Left Ankle).]
To cite this abstract in AMA style:Chimeno Hernandez A, Pérez-Alenda S, Carrasco JJ, Aguilar M, Haya S, Cid AR, Megías JE, Bonanad S, Querol F. Diagnosis and Management of Acute Hemarthrosis and Haemophilic Arthropathy in Spain Using Unified Clinical and Ultrasound Criteria: Preliminary Results [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/diagnosis-and-management-of-acute-hemarthrosis-and-haemophilic-arthropathy-in-spain-using-unified-clinical-and-ultrasound-criteria-preliminary-results/. Accessed September 22, 2023.
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