Background: Despite the close attention of researchers, the problem of preeclampsia is far from being solved. With preeclampsia, almost all endothelial functions are impaired: regulation of hemostasis, vascular tone, immune processes, vasopermeability.

Aims: The purpose of our work was to study the diagnostic role of soluble fibrin-monomer complexes (SFMC) in the development of preeclampsia.

Methods: We studied the state of the hemostasis system in 100 pregnant women with preeclampsia and in 30 women with physiological pregnancy in the third trimester. The study of the state of platelet, procoagulant and fibrinolytic links of the hemostasis system and their assessment were carried out in the dynamics of observation. The level of soluble fibrin monomer complexes (SFMC) was determined by the ortho-phenanthroline method using standard test systems “RFMK-test” from Tekhnologiya – Standart, Russia.

Results: The indices of the hemostasis system in pregnant women with preeclampsia in the third trimester differ significantly from those in women with the physiological course of pregnancy.
In pregnant women with preeclampsia in the third trimester was revealed, a statistically significant shortening of activated recalification time – 42.7 ± 0.8 sec compared to the control – 51.4 ± 0.4 sec (P <0.001).
When studying markers of blood activation, we found a significant increase in SFMC – 6.9 ± 0.7 mg / 100 ml in the main group, in contrast to the control group – 2.89 ± 0.11 mg / 100 ml (P <0.001). The presence of markers of intravascular blood coagulation  in pregnant women with severe preeclampsia indicate the activation of intravascular thrombus formation as a chronic form of DIC.

Conclusions: Analysis of observations of patients indicates the staging of the development of platelet hyperaggregation followed by hypercoagulation. An increase in the frequency of positive tests for the presence of SFMC was evidence of the intensification of intravascular blood coagulation.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/diagnostic-significance-of-definitions-soluble-fibrin-monomer-complexes-in-patients-with-preeclampsia/