Abstract Number: LPB0028
Meeting: ISTH 2021 Congress
Background: Pulmonary embolism (PE) and deep venous thrombosis (DVT) are considered to be in the same spectrum of venous thromboembolism (VTE). Risk factors for the development and outcomes after each may differ.
Aims: To evaluate the clinical characteristics, clinical and laboratory risk factors, and outcomes of pediatric patients with isolated DVT as compared to PE (PE with or without DVT).
Methods: In this retrospective single-center cohort study, we included consecutive patients < 21 years with radiologically confirmed PE or DVT between Jan 1, 2001, and Nov 4, 2020. Clinical and laboratory risk factors, treatment modalities, and outcomes were compared between the two. Statistical analysis was carried out using SPSS version 26.
Results: Of the 827 patients, 729 presented with DVT and 98 with PE. There was a bimodal age distribution in both groups. Univariate analysis showed that PE patients were more likely to be female, obese, have a history of oral contraceptives use, surgery, immobilization, and systemic lupus erythematosus whereas DVT patients were more likely to have a history of catheterization or dehydration (p <0.05). PE patients were more likely to have a high D-dimer, factor VIII, fibrinogen, Von Willebrand factor, positive anticardiolipin antibodies, lupus anticoagulant, anti-nuclear antibody (ANA), at presentation and on follow up (p < 0.05). On preliminary logistic regression, patients with PE had a high risk for recurrent VTE (OR 2.592, 95% confidence interval [CI] 1.249-5.380). Other risk factors associated with recurrence were catheterization (OR 2.987, 95% CI 1.668-5.348), high factor VIII (OR 3.466, 95% CI 1.063-11.304), and positive ANA (OR 5.926, (5% CI 1.083-34.423) at follow up.
Conclusions: Pediatric PE patients have unique risk factors and outcomes as compared to those with DVT. This finding needs to be confirmed in larger studies.
To cite this abstract in AMA style:Suryaprakash S, Sabo C, Farooqi A, Rajpurkar M. Difference is Risk Factors and Clinical Outcomes in Pediatric Patients with Deep Venous Thrombosis as Compared to Pulmonary Embolism [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/difference-is-risk-factors-and-clinical-outcomes-in-pediatric-patients-with-deep-venous-thrombosis-as-compared-to-pulmonary-embolism/. Accessed September 23, 2021.
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