Abstract Number: PB1308
Meeting: ISTH 2022 Congress
Background: In the follow-up of patients diagnosed with PE, either CTEPH or cancer can be identified. We hypothesized that cancer and CTEPH might share pathogenic pathways such as inflammation, cell proliferation, or apoptosis.
Aims: Analyze the proteomic profile of patients with CTEPH, uncomplicated PE and PE patients with occult cancer to identify proteins dysregulated in PE group compared to those with occult cancer and CTEPH.
Methods: Fourteen patients with CTEPH, 6 with venous thrombosis disease (VTD) who were subsequently diagnosed with cancer, and 7 with PE who did not present neither CTEPH nor occult cancer after 2 years follow-up were evaluated. Citrated plasma was obtained from all of them and used for protein quantification in a mass spectrometer by iTRAQ© labeling. After quality control and normalization, differential expression analysis was performed using the Kruskal-Wallis test with the Benjamini-Hochberg (BH) correction for multiple testing.
Results: A total of 382 proteins were determined in all groups, 28 were found to be differentially expressed in the 3 groups of patients. We selected five of them based on their under- or overexpression in the PE group, compared to the groups that developed cancer or CTEPH (Table 1).
Conclusion(s): The circulating proteins identified could help to differentiate patients with PE who are at risk for presenting subsequent cancer or CTEPH.
To cite this abstract in AMA style:Sánchez López V, Mendoza Zambrano E, Oto J, Arellano Orden E, Tura Ceide O, FONT C, Saez M, Medina P, Blanco I, Barberà J, Otero Candelera R. Differential proteomic profile of patients with Pulmonary Embolism (PE) related to events during follow-up: chronic thromboembolic pulmonary hypertension (CTEPH) or occult cancer. [abstract]. https://abstracts.isth.org/abstract/differential-proteomic-profile-of-patients-with-pulmonary-embolism-pe-related-to-events-during-follow-up-chronic-thromboembolic-pulmonary-hypertension-cteph-or-occult-cancer/. Accessed February 27, 2024.
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