Abstract Number: PB2181
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » Genetic Risk Factors of Thrombosis
Background: ABO blood group has been described to play a role in thrombosis risk, being higher in those no-O. Classical coagulation tests do not reflect the thrombophilic profile of patients. The thrombin generation test (TGT) is a promising tool to assess hemostatic disorders.
Aims: Evaluate ABO blood group prothrombotic risk by using the thrombin generation test.
Methods: This was a descriptive study including 37 healthy adult patients (48.65% males, 23 year-old median age (19-64 years old)). Patients were classified according to blood group: group A (n=13), group B (n=12), group O (n=12). Plasma samples were obtained to determine the prothrombin time (PT), activated partial thromboplastin time (aPTT) coagulation factor VIII (STA STAGO, France) and von Willebrand factor activity (vWF) (BCS, Siemens, Germany). Thrombin generation test (TGT) was performed by means of GENESIA device (STAGO, France) with Thromboscreen kit. The ethic committee of the institution approved the study. All included patients signed the informed consent.
Results: We found differences in time to peak (p=0.008) and in maximum peak (p=0.007) without thrombomodulin depending on patients’ blood group; differences were stablished between group B and O (4.1 vs 5.4 and 111.5 vs 79.4, respectively). Moreover, a correlation between peak time without thrombomodulin and factor VIII (r=0.37, p=0.025) was found. No differences were seen in any parameter after the addition of thrombomodulin. No correlation of TGT parameters with vWF was obtained.
No differences with aPTT and PT were found between groups. Those patients with group O had lower levels of vWF and factor VIII, having a good correlation between them (r=0.8, p< 0.001).
aPTT correlated with FVIII (r=-0.53, p< 0.001) and with vWF (r=-0.38, p=0.019).
Conclusions: Group B patients show a procoagulant profile according to TGT results. These findings suggest that TGT can identify a prothrombotic states related to ABO blood groups.
To cite this abstract in AMA style:
Marcos Jubilar M, Terrasa D, Palacios ML, Riego V, Tamariz LE, Lecumberri R, Páramo JA. Does blood Group Predicts Thrombosis Risk? A Pilot Study Assessing Thrombin Generation [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/does-blood-group-predicts-thrombosis-risk-a-pilot-study-assessing-thrombin-generation/. Accessed January 21, 2022.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/does-blood-group-predicts-thrombosis-risk-a-pilot-study-assessing-thrombin-generation/