DP-Filter, a Medical Device to Remove Edoxaban and Edoxaban-M4 from Plasma of Patients Taking Edoxaban

J. Favresse¹, C. Bouvy², R. Sirriez¹, P. Hainaut³, H. Yildiz³, A.-S. Delvigne², M. Hardy⁴, F. Mullier⁵, J.-M. Dogné¹, J. Douxfils^1,2

¹UNamur, Pharmacy, Namur, Belgium, ²QUALIblood s.a., Pharmacy, Namur, Belgium, ³Cliniques Universitaires Saint Luc, UCL, Internal Medicine, Brussels, Belgium, ⁴UCLouvain, Anesthesiology, Yvoir, Belgium, ⁵UCLouvain, Laboratory Medicine, Yvoir, Belgium

Abstract Number: PB0651

Meeting: ISTH 2020 Congress

Theme: Diagnostics and OMICs » Laboratory Diagnostics

Background: The impact of direct oral anticoagulants (DOACs) on hemostasis parameters is a clinical issue. The use of devices or techniques to overcome this type of interference is needed for the correct interpretation of hemostasis tests in patients taking DOACs.

Aims: This study aims at evaluating the efficiency of DP-Filter (Qualiblood, Belgium), a new and simple device to remove edoxaban and its more relevant M4-metabolite from patient samples.

Methods: Seventy-eight plasma samples obtained from 52 patients taking edoxaban were included in this study. DP-Filter was used to filter plasma. Edoxaban and edoxaban-M4 were then measured in both filtered and unfiltered plasma using a recently validated UHPLC-MS/MS method.

Results: The mean edoxaban and edoxaban-M4 concentrations measured in the unfiltered plasma were 128.0 ng/mL (95%CI 98.0-158.1 ng/mL) and 8.4 ng/mL (95%CI 5.8-11.0 ng/mL), respectively. The mean concentrations of edoxaban and edoxaban-M4 measured in the filtered plasma decreased to 0.0 ng/mL (95%CI 0.0-0.0 ng/mL) and 0.2 ng/mL (95%CI 0.1-0.3 ng/mL), respectively (< LOQ of the assay).

Conclusions: The DP-Filter is an effective, simple and ergonomic device to completely remove edoxaban and edoxaban-M4 from plasma of patients taking edoxaban.

To cite this abstract in AMA style:

Favresse J, Bouvy C, Sirriez R, Hainaut P, Yildiz H, Delvigne A-, Hardy M, Mullier F, Dogné J-, Douxfils J. DP-Filter, a Medical Device to Remove Edoxaban and Edoxaban-M4 from Plasma of Patients Taking Edoxaban [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/dp-filter-a-medical-device-to-remove-edoxaban-and-edoxaban-m4-from-plasma-of-patients-taking-edoxaban/. Accessed September 22, 2023.

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