Background: Axillary and subclavian vein thrombosis (ASVT) is a rare condition, and the lack of randomized trials results in insufficiently standardized treatment, especially regarding idiopathic type of ASVT.
Aims: This study aimed to investigate differences in treatment and outcomes of patients with idiopathic and other non-catheter-related ASVT.
Methods: In this single-center retrospective study, we analyzed the characteristics and outcomes of patients with non-catheter-related ASVT treated at University Hospital Center Zagreb from December 2008 to September 2020.
Results: 54 patients were analyzed with a median age of 38 years (18-82), 59% were male. Fourteen patients (26%) had idiopathic ASVT. They were treated with: warfarin 7, rivaroxaban 4, apixaban 2, dabigatran 1. Forty patients (74%) had apparent etiological factors of ASVT: 14 on-effort thrombosis without thoracic outlet syndrome (TOS), 7 TOS, 5 malignant disease, 6 antiphospholipid syndrome, 6 thrombophilia, and 2 other. They were treated with: warfarin (16), rivaroxaban (10), apixaban (5), LMWH (3), and 6 patients switched anticoagulant therapy (ACT). There was no statistical significant difference in ACT duration between idiopathic and provoked ASVT (8 vs 12 months, p=0,7108).
Seven patients (13%) had a relapse of venous thrombosis, 3 with idiopathic ASVT, and 3 relapses occurred during the ACT. There was no statistical significant difference in the relapse rate between idiopathic and provoked ASVT (p=0,5264) and between different anticoagulant drugs (p=0,088).
Conclusions: Results of our study showed similar duration and treatment outcome between idiopathic and other non-catheter-related ASVT. This finding indicates need for further research in prospective design with longer follow-up
To cite this abstract in AMA style:Sliskovic A, Vrkic Kirhmajer M, Narancic M, Sabol I, Vodanovic M, Boban A, Pulanic D. Duration and Treatment Outcomes between Idiopathic and Provoked Non-catheter-Related Axillary and Subclavian Vein Thromboses [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/duration-and-treatment-outcomes-between-idiopathic-and-provoked-non-catheter-related-axillary-and-subclavian-vein-thromboses/. Accessed September 24, 2021.
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