Abstract Number: PB0762
Meeting: ISTH 2020 Congress
Background: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Pulsed- high intensity focused ultrasound have been extensively studied as an effective method to treat thrombosis.
Aims: The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of extracorporeal B- mode ultrasound- guided pulsed- high intensity focused ultrasound- mediated inertial cavitation thrombolytic therapy accompanied by simultaneously intravenous air-contained sonicated dextrose albumin administration in this model.
Methods: Briefly, New Zealand White rabbits were submitted to thromboembolic occlusion by injecting autologous blood clots through carotid artery. Then treatment group underwent extracorporeal pulsed- high intensity focused ultrasound (F= 150 KHz, P= 25 W, PD= 250 ms) inertial cavitation therapy accompanied by simultaneously intravenous air-contained sonicated dextrose albumin (ASDA) (200ml/kg, 2-5 × 105 bubbles/ml) administration, wherein diagnostic B- mode ultrasound is combined with therapy system, with a goal of increased safety.
Results: Results from B-mode ultrasound imaging concurrent with extracorporeal pulsed- high intensity focused ultrasound therombolytic therapy, showed the generation of inertial cavitation in the carotid artey. Also, histopathology results, showed a significant reduction in the mean value for thrombus content at the embolic region in the treatment group compared with the other groups
Conclusions: Enhanced thrombolytic effect of extracorporeal pulsed- high intensity focused ultrasound, induced by inertial cavitation effect of ASDA microbubbles can cause to significantly reduce the thrombus content and dilate the luminal cross-sectional area at the embolic region and lower treatment time and reduce total costs of treatment.
To cite this abstract in AMA style:Mehrad H, Farhoudi M. Effect of B-Mode Ultrasound-Guided Pulsed – High Intensity Focused Ultrasound-Mediated Inertial Cavitation Thrombolytic Therapy Accompanied by Air-Contained Sonicated Dextrose Albumin Microbubbles Administration on Embolic Artery Occlusion [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/effect-of-b-mode-ultrasound-guided-pulsed-high-intensity-focused-ultrasound-mediated-inertial-cavitation-thrombolytic-therapy-accompanied-by-air-contained-sonicated-dextrose-albumin-microbubbles-adm/. Accessed September 22, 2023.
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