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Effect of B-Mode Ultrasound-Guided Pulsed – High Intensity Focused Ultrasound-Mediated Inertial Cavitation Thrombolytic Therapy Accompanied by Air-Contained Sonicated Dextrose Albumin Microbubbles Administration on Embolic Artery Occlusion

1Mehrad Research Lab, Division of Noninvasive Therapy, Tabriz, Iran, Islamic Republic of, 2Tabriz University of Medical Sciences, Neurosciences Research Center, Tabriz, Iran, Islamic Republic of

Abstract Number: PB0762

Meeting: ISTH 2020 Congress

Theme: Fibrinolysis and Proteolysis » Thrombolytic Therapy

Background: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Pulsed- high intensity focused ultrasound have been extensively studied as an effective method to treat thrombosis.

Aims: The aim of this study was to generate a rabbit model of carotid artery thromboembolic occlusion and the subsequent investigating the feasibility of extracorporeal B- mode ultrasound- guided pulsed- high intensity focused ultrasound- mediated inertial cavitation thrombolytic therapy accompanied by simultaneously intravenous air-contained sonicated dextrose albumin administration in this model.

Methods: Briefly, New Zealand White rabbits were submitted to thromboembolic occlusion by injecting autologous blood clots through carotid artery. Then treatment group underwent extracorporeal pulsed- high intensity focused ultrasound (F= 150 KHz, P= 25 W, PD= 250 ms) inertial cavitation therapy accompanied by simultaneously intravenous air-contained sonicated dextrose albumin (ASDA) (200ml/kg, 2-5 × 105 bubbles/ml) administration, wherein diagnostic B- mode ultrasound is combined with therapy system, with a goal of increased safety.

Results: Results from B-mode ultrasound imaging concurrent with extracorporeal pulsed- high intensity focused ultrasound therombolytic therapy, showed the generation of inertial cavitation in the carotid artey. Also, histopathology results, showed a significant reduction in the mean value for thrombus content at the embolic region in the treatment group compared with the other groups
(P< 0.05).

Conclusions: Enhanced thrombolytic effect of extracorporeal pulsed- high intensity focused ultrasound, induced by inertial cavitation effect of ASDA microbubbles can cause to significantly reduce the thrombus content and dilate the luminal cross-sectional area at the embolic region and lower treatment time and reduce total costs of treatment.

To cite this abstract in AMA style:

Mehrad H, Farhoudi M. Effect of B-Mode Ultrasound-Guided Pulsed – High Intensity Focused Ultrasound-Mediated Inertial Cavitation Thrombolytic Therapy Accompanied by Air-Contained Sonicated Dextrose Albumin Microbubbles Administration on Embolic Artery Occlusion [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/effect-of-b-mode-ultrasound-guided-pulsed-high-intensity-focused-ultrasound-mediated-inertial-cavitation-thrombolytic-therapy-accompanied-by-air-contained-sonicated-dextrose-albumin-microbubbles-adm/. Accessed September 22, 2023.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/effect-of-b-mode-ultrasound-guided-pulsed-high-intensity-focused-ultrasound-mediated-inertial-cavitation-thrombolytic-therapy-accompanied-by-air-contained-sonicated-dextrose-albumin-microbubbles-adm/