Abstract Number: PB1819
Meeting: ISTH 2020 Congress
Background: HIV infection is associated with varying degrees of inflammation and as the disease progresses, inflammation becomes severe and is associated with many of the complications seen in HIV infection. A novel marker for inflammation – Platelet-Lymphocyte ratio (PLR) is known to correlate with inflammation, atherosclerosis and platelet activation. We prospectively assessed the effect of cART on the PLR in HIV+ patients presenting to commence cART in Rivers State University Teaching Hospital.
Aims: This study aimed to evaluate the effect of Anti-retroviral Therapy on PLR, determine any significant relationship between the HIV Viral Load and PLR and acertain if the effect is sustained for up to 6 months into cART.
Methods: Consenting adults were recruited, 10mls of EDTA samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems).
Results: A total of 40 clients were recruited, with a mean age of 36.20 years, 14(35%) of them were males. Mean PCV, Platelet: Lymphocyte ratio and HIV VL at Month 0 were 31.65±7.30%, 7.82±2.90 and 215767.85±360338.04cp/ml respectively. There was a statistically significant increase (p < 0.001) in the haematocrit by the 6th month on cART, the reduction in Platelet: Lymphocyte count and of HIV VL by the 6th month was also significant (P< 0.001). Interestingly, PLR positively correlated with the VL at baseline (0.3676), however, there was a negative correlation at 3 months (-0125) and 6 months (-0.028).
Conclusions: The findings from this study support a growing body of evidence that cART significantly reduces the viral load and inflammation in HIV+ patients, however, it also shows that a low-level inflammation persists which may lead to a chronic inflammatory state, morbidity and mortality in this group of patients.
|HCT Month 0||31.650 ± 7.303||20.920||<0.001|
|HCT Month 3||36.435 ±4.291|
|HCT Month 6||38.960 ±2.707|
|VL Month 0||215767.850 ±360338.04||14..293||<0.001|
|VL Month 3||705.650 ± 684.220|
|VL Month 6||29.330 ±17.869|
|PLR Month 0||7.823 ±2.90||26.50||<0.001|
|PLR Month 3||5.648 ±1.439|
|PLR Month 6||4.721 ±1.053|
[Effect of cART ON Haematocrit, HIV Viral load, Platelet:Lymphocyte ratio]
To cite this abstract in AMA style:Omunakwe H, Moore-Igwe B, Maduka O, Eze EM, Christian SG. Effect of cART on Platelet:Lymphocyte Ratio in HIV Patients Initiating Treatment [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/effect-of-cart-on-plateletlymphocyte-ratio-in-hiv-patients-initiating-treatment/. Accessed January 26, 2022.
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