Abstract Number: PB0046
Meeting: ISTH 2020 Congress
Theme: Arterial Thromboembolism » Atherosclerosis
Background: Smooth muscle cell proliferation and migration from the medial layer into the intima, following an intravascular damage like angioplasty, causes neointimal hyperplasia.
It is great importance to treat neointimal hyperplasia through early stages and vascular restenosis should be prevented. There exists a range of treatment protocols for neointimal hyperplasia which can be divided into two main groups: invasive and non-invasive. Accordingly, detection and evaluation methods are again too vast, divided into the above same main groups.
Aims: In this study, we aimed to introduce a novel non-invasive treatment (Photodynamic therapy) for neointimal hyperplasia reduction, for which the evaluation procedure (a new computerized ultrasound image processing) is be based on a non-invasive method.
Methods: In the current study, we first induced neointimal hyperplasia in the common carotid artery of New Zealand white rabbits by arterial injury following balloon angioplasty for two minutes. After 4 weeks pathology results confirmed the induction of neointimal hyperplasia in all the rabbits´ arteries. At the end of four weeks, we performed extracorporeal red laser (ƛ= 632 nm, P= 500 mw) irradiation for 20 minutes, accompanied by sensitive drug, 5-aminolevulinic acid (10mg/Kg) administration (Photodynamic therapy) at the injury site of treatment group. Next, the rabbits were care given for two weeks. Arterial biomechanical parameters at the site of injury to be evaluated by a new computer based image processing and ultrasound were: resistance index, pulse index, radial strain and longitudinal strain.
Results: Our findings suggest the statistically meaningful decrease of resistance and pulse indexes and elevated radial and longitudinal strain of the treatment group in comparison with the other groups(p< 0.05).
Conclusions: Photodynamic therapy recovers arterial biomechanical parameters by ameliorating inflammation and smooth muscle cells at the injury site.
To cite this abstract in AMA style:
Mehrad H, Najafzadeh A. Effect of Photodynamic Therapy on Arterial Biomechanical Parameters in a Rabbit Carotid Artery Model of Neointimal Hyperplasia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/effect-of-photodynamic-therapy-on-arterial-biomechanical-parameters-in-a-rabbit-carotid-artery-model-of-neointimal-hyperplasia/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/effect-of-photodynamic-therapy-on-arterial-biomechanical-parameters-in-a-rabbit-carotid-artery-model-of-neointimal-hyperplasia/