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Effect of Streptokinase-Loaded Microbubbles-Mediated B-Mode Ultrasound-Guided Sono-Photomechanic Combination Thrombolytic Therapy on Atherothrombotic Stenosis

H. Mehrad1, M. Farhoudi2

1Medical Biology Research Center, Kermanshah University of Medical Sciences, Division of Noninvasive Therapy, Tabriz, Iran, Islamic Republic of, 2Tabriz University of Medical Sciences, Neurosciences Research Center, Tabriz, Iran, Islamic Republic of

Abstract Number: PB0763

Meeting: ISTH 2020 Congress

Theme: Fibrinolysis and Proteolysis » Thrombolytic Therapy

Background: Thrombus formation on a disrupted atherosclerotic plaque is a key event that leads to atherothrombosis.

Aims: The aim of this study was to generate a hamster model of abdominal aorta atherothrombotic stenosis with morphological similarities to the human disease and the subsequent assessment of the reliability of B- mode ultrasound- guided sono- photomechanic combination thrombolytic therapy accompanied by streptokinase- loaded microbubbles administration in this model.

Methods: Briefly, Golden Syrian hamsters were submitted to abdominal aorta atherothrombotic stenosis by primary balloon injury followed by a 1.5% cholesterol- rich diet injury for 12 weeks and finally perivascularly severe cold injury. Then treatment group underwent extracorporeal pulsed- high intensity focused ultrasound (F= 150 KHz, P= 25 W, PD= 250 ms)- mediated inertial cavitation therapy and catheter- based Q-switched Nd: YAG laser (F= 532 nm, P= 25 W, PD= 15 ns)- mediated inertial cavitation therapy accompanied by simultaneously intravenous streptokinase (25000 Units/kg)- loaded PESDA (Perfluorocarbon- Exposed Sonicated Dextrose Albumin) microbubbles (100ml/kg, 2-5 × 105 bubbles/ml) administration, wherein diagnostic B- mode ultrasound is combined with therapy system, with a goal of increased safety.

Results: Results from color Doppler and B-mode ultrasonography and histopathology, showed a significant reduction in the mean value for blood mean velocity and the percentage of luminal cross-sectional area of stenosis and a significant increase in the mean value for blood volume flow at the stenotic region in the treatment group compared with the other groups (p< 0.05).

Conclusions: Enhanced thrombolytic effect of sono- photomechanic combination therapy, induced by inertial cavitation effect of microbubbles can cause to enhance the anti-thrombotic effect of streptokinase and significantly dilate the luminal cross- sectional area of stenosis.

To cite this abstract in AMA style:

Mehrad H, Farhoudi M. Effect of Streptokinase-Loaded Microbubbles-Mediated B-Mode Ultrasound-Guided Sono-Photomechanic Combination Thrombolytic Therapy on Atherothrombotic Stenosis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/effect-of-streptokinase-loaded-microbubbles-mediated-b-mode-ultrasound-guided-sono-photomechanic-combination-thrombolytic-therapy-on-atherothrombotic-stenosis/. Accessed March 3, 2021.
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