Abstract Number: PB0581
Meeting: ISTH 2020 Congress
Background: To date, anticoagulant therapy with vitamin K antagonists requires the determination of known standard indicators of the hemostasis system, which is often insufficient, due to the development of bleeding, retrombosis, even in the presence of laboratory monitoring.
Aims: of the study is to analyze the effect of warfarin therapy on the dynamics of hypercoagulation syndrome in patients with DVT.
Methods: A retrospective study was carried out on the basis of the anticoagulant сlinic. Methodologically the study included 3 points: 1- 1st day of heparin therapy and warfarin; 2 – 7 day of warfarin therapy; 3 – the 15th day of warfarin therapy. At 68 patients with deep vein thrombosis were examined in the AC for changes and comparability of parameters global and standard tests of the hemostasis system with the assessment of dynamics by ultrasound dopplerography.
Results: On the 1st and 7th day of warfarin administration, the formation of spontaneous plasma clots without an activator was observed in 11 and 5 patients respectively at the 1st minute. The initial growth rate of the clot on the 1st day of the study, which characterizes the coagulation initiation phase, was 31.0 [17.0 – 43.0] mcm/min (reference value 38.0 – 56.0 mcm/min), which reflected the hypocoagulation during treatment with heparins. The standard levels of indicators of hemostasis of the AVK to 15 days of the effectiveness of therapy was achieved in terms of international normalized ratio and D-dimer, data was recorded on doppler ultrasound in the form of recanalization of blood flow by 15 days.
Conclusions: The expediency of local and global methods of hemostasis system at the stage of initiation of warfarin dose together with ultrasound control of blood flow in patients with deep vein thrombosis is shown.
To cite this abstract in AMA style:Vorobyeva N, Alexseeva A. Effect of Vitamin K Antagonist Therapy on the Dynamics of Hypercoagulation Syndrome in Patients with Deep Vein Thrombosis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/effect-of-vitamin-k-antagonist-therapy-on-the-dynamics-of-hypercoagulation-syndrome-in-patients-with-deep-vein-thrombosis/. Accessed February 27, 2024.
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