Abstract Number: PB1392
Meeting: ISTH 2020 Congress
Theme: Platelet Disorders and von Willebrand Disease » Antiplatelet Therapy
Background: Effective antiplatelet treatment is essential in secondary prevention of atherosclerotic stroke. As generally recommended, acetylsalicylic acid (ASA) in dose 100-325 mg daily is the main drug administered after thrombolysis to patients with acute ischemic stroke.
Aims: Systematic monitoring of onset ASA effect during the first four days after the loading dose 500 mg ASA intravenously and subsequent daily maintenance dose 100 mg ASA orally.
Methods: Evaluated a group of 23 patients admitted with acute ischemic stroke to the neurological department.
Blood samples for platelet function monitoring were drawn in four consecutive days. The first initial sample was drawn 24 hours after thrombolysis, immediately before the loading dose 500 mg ASA.
The second sample was taken 24 hours later and 3rd and 4th sample was taken after the maintenance doses. The samples were analyzed by multiple electrode aggregometry on Multiplate® Analyser (Roche) using ASPItest. Cut-off value for effective antiplatelet therapy was determined
≤30 U.
Results: The initial 500 mg loading dose of ASA induces effective antiplatelet therapy in 79% of patients 24 hours after drug administration. Three days later ASPItest values decreased in 100 % of patients but only 52 % accomplished effective antiplatelet therapy. 35 % of patients did not achieved effective therapy but their values were close to cut-off (30-37 U). Results of remaining 3 patients (13%) were in the range 42-66 U.
Conclusions: We can demonstrate high efficacy of the loading dose 500 mg ASA intravenously 24 hours after thrombolysis in patients with acute ischemic stroke.
According to our analysis, 35% of patients would benefit from an ASA maintenance dose higher than 100 mg daily.
Supported by: MH CZ – DRO (University Hospital Pilsen – FNPl, 00669806)
To cite this abstract in AMA style:
Bultasova L, Hajsmanova Z, Sigutova P, Rohan V, Polivka J. Efficacy of Antiplatelet Therapy in Patients with Acute Ischemic Stroke Treated with Acetylsalicylic Acid [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/efficacy-of-antiplatelet-therapy-in-patients-with-acute-ischemic-stroke-treated-with-acetylsalicylic-acid/. Accessed April 17, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/efficacy-of-antiplatelet-therapy-in-patients-with-acute-ischemic-stroke-treated-with-acetylsalicylic-acid/