Abstract Number: PO114
Meeting: ISTH 2021 Congress
Background: One of the areas of clinical medicine is the study of the mechanisms of adaptation of the vascular endothelium as a risk factor for thrombosis.
Aims: The study aimed to determine the possible relationship between the development of endothelial dysfunction and the antioxidant system with modifiable risk factors in a trans-latitudinal flight in the Arctic.
Methods: The prospective study included 32 crewmembers of the research vessel «Mikhail Somov» during the «TransArctic-2019» integrated marine scientific expedition. Venous blood sampling was carried out before the went on a voyage (zero point) to the city of Arkhangelsk (64° 33′ north latitude 40° 32′ east longitude) and at the highest point of the expedition – Hayes Island (80° 34′ north latitude 57° 41′ east longitude). The determination of the concentration of endothelin-1 and the total antioxidant ability of serum (AOS) by enzyme-linked immunosorbent assay. The study was supported by a grant from the Russian Foundation for Basic Research – project No. 18-00-00814-COMFI (18-00-00478).
Results: Statistically differences were obtained in the concentration of endothelin at zero (M = 4,79 ± 2,1) pg/ml and high points (M = 7,02 ± 2,42) pg/ml, t = -3,6532, df = 31, p < 0,001, the concentration of endothelin-1 significantly increases, which indicates the first signs of the formation of maladaptation of the vascular endothelium in the form of vasoconstriction. 84,4 % of crewmembers at a high point showed a high overall antioxidant ability, which may indicate compensation for antioxidant defence mechanisms. It was shown that AEC in the study group among smokers was statistically significantly higher than in non-smokers.
Conclusions: Moreover, the predominance of high AOC among the crew of the vessel indicates an increased oxidative load on the human body to neutralize the excess amount of reactive oxygen species.
To cite this abstract in AMA style:Vorobyeva N, Vorobyeva A. Endothelin and General Oxidative Ability as Markers of Deadaptation in Sailors in the conditions of the Arctic Flight [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/endothelin-and-general-oxidative-ability-as-markers-of-deadaptation-in-sailors-in-the-conditions-of-the-arctic-flight/. Accessed November 28, 2021.
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