Background: The presence of platelet microparticles in hypertension has been reported, and these are believed to play a role in mediating target organ injury in severe hypertension.

Aims: This project aimed to assess the coagulation profile of non-diabetic hypertensive patients.

Methods: Fifty (50) non-diabetic hypertensive patients at the medical outpatient (MOP) Department of University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria were investigated, they comprised of 25 males and 25 females. Besides, fifty age and sex-matched healthy subjects served as the control group. The University of Nigeria Research Ethics Committee approved the study. The coagulation profile and biochemical analysis carried out include: prothrombin Time, (PT) Activated partial Thromboplastin Time (APTT), Fibrinogen Assay, platelet count, Fasting Blood Glucose, sodium ion, Potassium ion, Chloride ion, Bicarbonate ion(HCO₃^–), Urea, Creatinine, Alkaline phosphatase, Total Bilirubin (TB), Conjugated Bilirubin, SGOT and SGPT.

Results: The Mean age (years) and range for the hypertensive patients was 58(40-78) and for the control subjects 59(48-75). The following variables show significant differences between the hypertensive group and the controls; PT 13.76 ± 0.20 and 13.18 ± 0.15 p-value (0.0248).  Fibrinogen Assay 5.45 ± 0.27 and 3.16 ± 0.10 (<0.0001); SGOT 14.82 ± 0.19 and 13.64 ± 0.18 (<0.0001); D.B 0.56 ± 0.01 and 0.51 ± 0.01 (0.0316); HCO₃^–21.46 ± 0.31 and 26.16 ± 0.69 (<0.0001); Urea 34.74±0.9371 and 28.68 ± 0.91 (<0.0001); Creatinine 0.93 ± 0.02 and 1.00 ± 0.01 (0.0008) respectively.

Conclusions: The increased PT and fibrinogen in the non-diabetic hypertensive subjects may indicate a hypercoagulable state of patients recruited for this study.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/evaluation-of-fibrinogen-level-in-non-diabetic-hypertensive-patients-at-the-university-of-nigeria-teaching-hospital-ituku-ozalla/