Abstract Number: PB1056
Meeting: ISTH 2022 Congress
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder. The clinical biomarkers like neutrophils to lymphocytes ratio (NLR) and platelet to lymphocytes ratio (PLR) can be used as differential diagnostic tool in various diseases.
Aims: The current study was planned to evaluate utility of NLR and PLR in ITP diagnosis and their association with disease prognosis and response to treatment.
Methods: A case control study (1:1) was conducted from January 2015 to December 2017 with 111 ITP patients and 111 healthy controls. Peripheral blood was collected and CBC was recorded using Sysmex XN-1000.The calculation of NLR and PLR was done using absolute value of neutrophils, lymphocytes and platelets counts. The significant difference (p= < 0.05) between ITP patients and healthy control groups was determined by Kruskal wallis test. Dunn’s test and spearman’s correlation test was performed to evaluate platelet count correlation with IPF using SPSS ver.23.
Results: Low hemoglobin and platelet counts with high total leucocyte count (TLC) and IPF were recorded in ITP patients as compared to healthy individuals (p= < 0.05).Among all groups of ITP patients, lowest platelet count was observed in ND-ITP group (median(IQR): 2(3.8)x109/l ). The NLR correlated well with the persistence of disease and was found higher in P-ITP. The PLR was significantly low in ND-ITP, P-ITP, C-ITP, R-ITP and compared to controls with p= < 0.001.
Conclusion(s): Hence, it can be concluded that NLR and PLR ratios can be used in predicting prognosis and response to treatment in ITP and to some extend the severity of disease.
To cite this abstract in AMA style:
Mukry S, Arshad A, Shamsi T. Evaluation of Neutrophil Lymphocytes Ratio and Platelets Lymphocytes Ratio in Immune thrombocytopenic purpura [abstract]. https://abstracts.isth.org/abstract/evaluation-of-neutrophil-lymphocytes-ratio-and-platelets-lymphocytes-ratio-in-immune-thrombocytopenic-purpura/. Accessed March 21, 2024.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/evaluation-of-neutrophil-lymphocytes-ratio-and-platelets-lymphocytes-ratio-in-immune-thrombocytopenic-purpura/