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Extracorporeally Thrombolytic Therapy of Embolic Common Carotid Artery Using Q-switched Nd:YAG Laser and Confocal Dual Pulse Electrohydraulic Shock Waves Accompanied by PESDA Microbubbles Administration

1Islamic Azad University, Basic Sciences Faculty, Department of Physics, Tabriz Branch, Tabriz, Iran, Islamic Republic of, 2Mehrad Research Lab, Division of Translational Development of Noninvasive Treatments, Tabriz, Iran, Islamic Republic of, 3Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran, Islamic Republic of

Abstract Number: PO104

Meeting: ISTH 2021 Congress

Theme: Arterial Thromboembolism » Cerebrovascular Disorders

Background: An embolism is the lodging of an embolus, a blockage-causing piece of material, inside a blood vessel. The embolus may be a blood clot (thrombus), a fat globule (fat embolism), a bubble of air or other gas (gas embolism), amniotic fluid (amniotic fluid embolism), or foreign material. A thin- cap atheromatous plaque may rupture with high risk of subsequent thromboembolism- mediated acute clinical events such as acute stroke.

Aims: The aim of this study was to investigating the feasibility of extracorporeally and simultaneously application of Q-switched Nd:YAG laser and electrohydraulic shock waves accompanied by PESDA microbubbles administration on clot embolism reduction in the hamster carotid artery.

Methods: Briefly, golden Syrian hamsters were submitted to common carotid artery thromboembolism. Then treatment group underwent extracorporeally and simultaneously Q-switched Nd:YAG laser (λ= 532 nm, P= 10 w, PD= 5 ns) therapy and confocal dual pulse electrohydraulic shock wave (V= 10 kv, F= 0.2 Hz, Impulses= 100 and V= 15 kv, F= 0.5 Hz, Impulses= 150) therapy accompanied by PESDA microbubbles (100 ml/kg, 2- 5 × 105 bubbles/ml) administration. Blood volume flow and blood mean velocity were measured by color Doppler ultrasonography. Moreover, percentage of luminal cross-sectional area of stenosis was measured by B-mode ultrasound at the occluded region. Moreover, occluded region was evaluated by histopathology.

Results: Quantitative ultrasonography and histopathological results showed a significant reduction in the mean value for blood mean velocity and the percentage of luminal cross-sectional area of stenosis and a significant increase in the mean value for blood volume flow in the treatment group compared with the other groups (P < 0.05).

Conclusions: Enhanced thrombolytic effect of mechanical inertial cavitation effect of Q-switched Nd:YAG laser- induced by collapsed PESDA microbubbles and confocal dual pulse electrohydraulic shock waves, can cause to reduce the thrombosis and significantly dilate the luminal cross-sectional area of stenosis.

To cite this abstract in AMA style:

Mehrad H, Farhoudi M. Extracorporeally Thrombolytic Therapy of Embolic Common Carotid Artery Using Q-switched Nd:YAG Laser and Confocal Dual Pulse Electrohydraulic Shock Waves Accompanied by PESDA Microbubbles Administration [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/extracorporeally-thrombolytic-therapy-of-embolic-common-carotid-artery-using-q-switched-ndyag-laser-and-confocal-dual-pulse-electrohydraulic-shock-waves-accompanied-by-pesda-microbubbles-administrati/. Accessed June 25, 2022.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/extracorporeally-thrombolytic-therapy-of-embolic-common-carotid-artery-using-q-switched-ndyag-laser-and-confocal-dual-pulse-electrohydraulic-shock-waves-accompanied-by-pesda-microbubbles-administrati/