Abstract Number: PO104
Meeting: ISTH 2021 Congress
Background: An embolism is the lodging of an embolus, a blockage-causing piece of material, inside a blood vessel. The embolus may be a blood clot (thrombus), a fat globule (fat embolism), a bubble of air or other gas (gas embolism), amniotic fluid (amniotic fluid embolism), or foreign material. A thin- cap atheromatous plaque may rupture with high risk of subsequent thromboembolism- mediated acute clinical events such as acute stroke.
Aims: The aim of this study was to investigating the feasibility of extracorporeally and simultaneously application of Q-switched Nd:YAG laser and electrohydraulic shock waves accompanied by PESDA microbubbles administration on clot embolism reduction in the hamster carotid artery.
Methods: Briefly, golden Syrian hamsters were submitted to common carotid artery thromboembolism. Then treatment group underwent extracorporeally and simultaneously Q-switched Nd:YAG laser (λ= 532 nm, P= 10 w, PD= 5 ns) therapy and confocal dual pulse electrohydraulic shock wave (V= 10 kv, F= 0.2 Hz, Impulses= 100 and V= 15 kv, F= 0.5 Hz, Impulses= 150) therapy accompanied by PESDA microbubbles (100 ml/kg, 2- 5 × 105 bubbles/ml) administration. Blood volume flow and blood mean velocity were measured by color Doppler ultrasonography. Moreover, percentage of luminal cross-sectional area of stenosis was measured by B-mode ultrasound at the occluded region. Moreover, occluded region was evaluated by histopathology.
Results: Quantitative ultrasonography and histopathological results showed a significant reduction in the mean value for blood mean velocity and the percentage of luminal cross-sectional area of stenosis and a significant increase in the mean value for blood volume flow in the treatment group compared with the other groups (P < 0.05).
Conclusions: Enhanced thrombolytic effect of mechanical inertial cavitation effect of Q-switched Nd:YAG laser- induced by collapsed PESDA microbubbles and confocal dual pulse electrohydraulic shock waves, can cause to reduce the thrombosis and significantly dilate the luminal cross-sectional area of stenosis.
To cite this abstract in AMA style:
Mehrad H, Farhoudi M. Extracorporeally Thrombolytic Therapy of Embolic Common Carotid Artery Using Q-switched Nd:YAG Laser and Confocal Dual Pulse Electrohydraulic Shock Waves Accompanied by PESDA Microbubbles Administration [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/extracorporeally-thrombolytic-therapy-of-embolic-common-carotid-artery-using-q-switched-ndyag-laser-and-confocal-dual-pulse-electrohydraulic-shock-waves-accompanied-by-pesda-microbubbles-administrati/. Accessed June 25, 2022.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/extracorporeally-thrombolytic-therapy-of-embolic-common-carotid-artery-using-q-switched-ndyag-laser-and-confocal-dual-pulse-electrohydraulic-shock-waves-accompanied-by-pesda-microbubbles-administrati/