Abstract Number: PB0185
Meeting: ISTH 2020 Congress
Background: Factor XII is believed to play a role tissue repair and the formation of blood vessels Its definite role is still unclear, because many cases of FXII deficit experience thrombotic events, instead of a bleeding problem. Moreover most of them are asymptomatic.
Aims: To show the role of Factor xII in the coagulation
Methods: Case report.
Results: A 25 year primigravida presented with normal pregnancy and delivery at 39 weeks.A healthy baby was born by normal vaginal delivery. Seven days after mother came with swollen hot and sick leg . I have indicated Doppler ultrasonography of the lower limbs Dimer and checkup of coagulation. The results – deep vein thrombosis in the right lower leg, elevated DD values correlated with Doppler finding and recent delivery, but the surprise was the abnormal coagulation status – prolonged aPTT 45, 43,48 sec (three samples were taken, three different days, the plasma sample operated manual and automatic ) Any past history of abnormal spontaneous bleeding episodes was not found, without prolonged and profuse bleeding even after childbirth 7 days ago.Mixing probe was – with complete correction of aPTТ, suggesting factor deficiency.Deficit was suspected, but who and how much? And why in such a deficit, thrombosis is presenting,is there a correlation between the deficit and the thrombosis, and why there was no postpartum hemorrhage, as expected with coagulation deficiency? Our conclusion was confirmed in a reference center and a coagulation factor deficiency was determined. It was a factor XII deficit 27% activity.
Conclusions: The therapy was aimed at treating deep vein thrombosis while treatment for this disorder is usually not necessary since bleeding abnormalities only mild or most often nonexistent. Factor XII deficiency should be a risk factor for bleeding episodes as result of reduced coagulation factors, or thrombosis risk- in our case-as a consequence of reduced fibrinolysis activity.
To cite this abstract in AMA style:Stambolieva D, Shorova M, Malinova T, Ortakovska S, Gjorgjevska V. Factor XII Deficiency – A Very Rare Coagulation Disorder: Case Report [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/factor-xii-deficiency-a-very-rare-coagulation-disorder-case-report/. Accessed December 1, 2022.
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