Abstract Number: PB2567
Meeting: ISTH 2020 Congress
Background: Preeclampsia is the hypertensive pregnancy disorder accompanied by proteinuria occurring after 20th weeks of gestation. Despite of well-known role of genetic inheritance in preeclampsia, limited data are reported on the familial preeclampsia in Pakistani population.
Aims: The aim of this study was to determine if family history of preeclampsia and hypertension in Pakistani population may be used as efficient and cost-effective predictor variables for preeclampsia in resource limited country.
Methods: This case control study was conducted at the Liaquat University of Medical and Health sciences (LUMHS), Jamshoro, Pakistan. A total of 250 pregnant women (125 cases and 125 controls), matched for age, parity and ethnicity were recruited after approval from the Ethical Review Committee, LUMHS. A written informed consent was taken from all the participants. All the demographic and detailed clinical data including family history and previous history of preeclampsia was recorded and pedigree drawn.
Results: In the current study, risk for preeclampsia increased to 1.74 times in women with positive family history of hypertension, whereas risk further increased to more than 7 times with positive family history of preeclampsia (Table I). The majority of the patients reported affected mother, sister and aunt in their families. The maximum numbers of member affected were 4; reported in one family involving sister, aunt, first cousin and niece. The 26.3% patients with familial preeclampsia had previous history of preeclampsia.
|Family history (FH)||Preeclamptics||Controls||Odds ratio||95% Confidence Interval||P-value|
|+FH of hypertension||48 (38.4%)||33(26.4%)||1.74||1.01-2.97||0.0436|
|+FH of preeclampsia||19 (15.2%)||3(2.4%)||7.3||2.09-25.3||0.0018|
[Comparison of the family history of hypertension and preeclampsia in preeclamptics and controls]
Conclusions: The increased likelihood of preeclampsia among women with familial hypertension and preeclampsia and previous history of preeclampsia is consistent with genetic susceptibility affecting families. Ruling out family history may serve as a predictive variable for better prevention and management.
To cite this abstract in AMA style:Khidri FF, Waryah AM. Family History of Preeclampsia and Hypertension: A Predictor of Preeclampsia in a Resource Limited Country [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/family-history-of-preeclampsia-and-hypertension-a-predictor-of-preeclampsia-in-a-resource-limited-country/. Accessed August 16, 2022.
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