Abstract Number: PB0318
Meeting: ISTH 2021 Congress
Background: The survival and growth of endometrioid implants are associated with a number of pathogenetic factors: inflammatory process, dysregulation of immunity, apoptosis inhibition, activation of angiogenesis processes, and local hormonal impairments. Recently, the changes of indicators of coagulation and fibrinolysis were revealed in patients with endometriosis. However, the presence of hemostasis violations and their severity in female patients with endometriosis remain controversial.
Aims: We were made the effort to assess соagulation potential using test of Thrombodynamics.
Methods: Hemostasis indicators in peripheral blood of 29 patients with endometriomas (mean age 26.9±3.5 years) were studied. Investigations were carried out using laboratory diagnostic system “Thrombodynamic register T-2”. The process of spatio-temporal formation of fibrin clot was registered: in a series of pictures received (Pic.1), the dependence of the size and area of spontaneous clots on time was evaluated and the numerical parameters of coagulation activity.
Results: It was determined that in female patients with endometriomas, the shift to hypercoagulation was found as compared to norm. The trend to expressed growth of a series of indicators was revealed: the speed of clot growth of 35.1+/-9.1 mkm/min (normal growth 20 – 30 mkm/min); initial speed of clot growth of 59.3+/-8.6 mkm/min (norm of 38 – 56 mkm/min), stationary speed of clot growth of 33.2+/-7.9 mkm/min (normal 20 – 29 mkm/min), and clot size of 1243+/-255 mkm (normal 800 – 1200 mkm). In 7 female patients (24.1%), the spontaneous clots were registered. The data obtained indicate a state of hypercoagulation in women with endometriosis and reflect а close relationship between coagulation and inflammation.
Conclusions: The data demonstrate alterations in hemostasis system of patients with endometriosis in direction of hypercoagulation connected with development of systemic inflammation. Thrombodynamic indices may be assessed not only as potential diagnostic markers but also as important characteristic for decoding of some pathogenetic aspects of endometriosis.
To cite this abstract in AMA style:Vasilenko I, Lifenko R, Gasparyan S, Kardashova Z, Rusanova E. Features of the Coagulation Potential of Blood in Patients with Endometriosis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/features-of-the-coagulation-potential-of-blood-in-patients-with-endometriosis/. Accessed December 5, 2021.
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