Abstract Number: PB2002
Meeting: ISTH 2020 Congress
Background: Granulomatosis with polyangiitis (GPA) is a multisystem inflammatory autoimmune disease characterized by the presence of necrotizing vasculitis of small and medium vessels with granuloma formation in various organs associated with antineutrophil cytoplasmic antibody (ANCA) presence.
Aims: Assessment of fibrinolytic activity in GPA patients to explain mechanisms that might be responsible for thrombotic manifestations of the disease.
Methods: Assessment of fibrinolytic activity in GPA patients to explain mechanisms that might be responsible for thrombotic manifestations of the disease.
Results: In GPA patients CLT, plasminogen activity and tPA antigen concentration were significantly higher than those of the healthy controls (119.00 vs 95.8; 109.95 vs 98.90 and 9.73 vs 7.02 respectevily; p< 0.05). There were no significant differences between PAI-1 antigen concentrations and alfa2-antiplasmin activity. Similarly in patients in remission, the same parameters were significantly higher (p< 0.05) than in controls. Clot lysis time and plasminogen activity were significantly higher only between patients in acute phase of the disease and controls (p< 0.05). There were no significant differences in parameters measured between patients in remission those in acute phase of their disease.
Conclusions: We observed an enhanced activity of the fibrinolytic parameters in patient with GPA, irrespective of the disease activity which may be secondary to an increased thrombotic activity in GPA.
To cite this abstract in AMA style:Iwaniec T, Musiał J, Zaręba L, Celińska-Lowenhoff M. Fibrinolytic Activity in Patients with Granulomatosis with Polyngiitis (GPA) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/fibrinolytic-activity-in-patients-with-granulomatosis-with-polyngiitis-gpa/. Accessed August 15, 2022.
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