Abstract Number: PB0541
Meeting: ISTH 2020 Congress
Background: The Clauss assay is the assay most often used for measuring fibrinogen. However, also the FIBTEM-assay (determined using thromboelastometry (ROTEM)) can be used to estimate fibrinogen levels. A major advantage of the FIBTEM is that it can provide information about the fibrinogen levels within a few minutes, while the Clauss assay needs 30-60 minutes before results are available.
Aims: To investigate the correlation between results from the FIBTEM-assay and fibrinogen concentrations, as measured by the Clauss assay.
Methods: 116 patients for whom both ROTEM analyses and a fibrinogen measurement using the Clauss assay were available, acquired in May or June 2019 in the Erasmus Medical Center in Rotterdam, were included. This were mostly patients with major trauma or large surgery (cardiac surgery or liver transplantation). In addition, ROTEM and Clauss measurements from 75 healthy subjects were included. Spearman correlation was used to determine the association between both assays.
Results: The correlations between FIBTEM parameters and fibrinogen levels measured by the Clauss assay were strong in patients (Spearman’s correlation coefficients (rs) above 0.82 (p< 0.001) for all subgroups) and moderate for healthy subjects (rs=0.68, p< 0.001) (Figure 1). The correlation between early FIBTEM parameters (clot firmness at 5 or 10 minutes) and the maximum clot firmness (MCF) was almost perfect (rs above 0.96).
Conclusions: Overall, strong correlations were found between the Clauss assay and several FIBTEM parameters, which suggests that early FIBTEM parameters can be used to determine fibrinogen levels in various patient groups. This indicates that FIBTEM parameters are usable for fast evaluation of fibrinogen levels in critical medical situations.
To cite this abstract in AMA style:de Vries JJ, Snoek CJM, Veen CSB, Kruip MJHA, de Maat MPM. FIBTEM Parameters Correlate Well with the Fibrinogen Concentration Measured by the Clauss Assay in Patients and Healthy Subjects [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/fibtem-parameters-correlate-well-with-the-fibrinogen-concentration-measured-by-the-clauss-assay-in-patients-and-healthy-subjects/. Accessed December 1, 2022.
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