Abstract Number: PB0065
Meeting: ISTH 2020 Congress
Background: The worldwide prevalence of cardiometabolic disorders among young adults has increased in the last years. However, gender differences in cardiometabolic risk factors not well understood.
Aims: To compare serum biomarkers of cardiometabolic risk factors in young men and women.
Methods: A cross-sectional study was conducted in men and women of outpatient department. Inclusion criteria: age 18-44 years, consent to participate. Exclusion criteria: secondary hypertension, diabetes mellitus. 251 adults were divided into 2 groups: gr. 1 – 124 men (49.4%) aged 27 [21-36] years (BMI 26,3 [25,1-27,8] kg/m2, WC 95 [91,6-96,4] cm); gr. 2 – 127 women (50.6%) aged 35 [26-41] years (BMI 24,5 [23,1-25,9] kg/m2, WC 82 [78-85,1] cm). The frequency of hypertension, abdominal obesity, dyslipidemia and impaired carbohydrate metabolism was similar among man and women. Leptin, adiponectin, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), endothelin-1, angiotensin II, fibrinogen, type 1 plasminogen activator inhibitor (PAI-1) were determined by ELISA. The data are presents as M±SD and Me [Q25-Q75]. Statistical significance was defined as p< 0.05.
Results: Women had statistically higher levels of leptin (34.6 [13.8-49.1] vs 15.5 [4.4-16.2] ng/L, p< 0.001), adiponectin (8.9 [7.5 -11.7] vs 7.9 [4.9-10.0], p=0.01) µm/L and fibrinogen (3.9 [3.4-4.5] vs 3.4 [2.8-4.0], p< 0.001) g/l compared to men. Men had significantly higher concentrations of angiotensin II (9.1 [6.4-24.4] vs 8.5 [5.0-15.5], p=0.04) ng/ml and PAI-1 (399.7 [264.1-597.9] vs 342.3 [221.9-453.5], p=0.02) ng/ml and IL-10 (6.3 [5.7-6.9] vs 5.2 [4.1-5.5], p=0.03) pg/ml. We did not find any other gender significant differences between IL-1β, IL-6, TNF-α and endothelin-1.
Conclusions: In young persons we found gender differences between adipokines (leptin, adiponectin), anti-inflammatory cytokines (IL-10), vasopressors (angiotensin II) and prothrombotic factors (fibrinogen, PAI-1). Further research is encouraged to determine the efficacy of applying these biomarkers to diagnosis and treatment in a clinical setting.
To cite this abstract in AMA style:Chulkov V, Vereina N, Chulkov V, Sinitsin S, Sumerkina V, Lenets E, Tarasova O, Gavrilova E. Gender-Associated Cardiometabolic Biomarkers in Young Adults [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/gender-associated-cardiometabolic-biomarkers-in-young-adults/. Accessed December 3, 2021.
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