Abstract Number: PB0352
Meeting: ISTH 2020 Congress
Background: Hypercoagulability occurs in NS with episodes of thrombotic complications.
Aims: This study evaluated the haemostatic profile of Nigerian children with NS and the relationship between haemostatic variables and the disease states.
Methods: Forty-six children with NS (2 -18 years) attending the Paediatric Nephrology Clinic of the University of Nigeria Teaching Hospital Enugu and an equal number of age and gender-matched healthy controls were studied. APTT and PT were assayed manually. Fibrinogen was assayed with a semi- automated Coagulometer (KHB202 Kinghawk, China), Antithrombin (AT) by ELISA (Mindray MR-96A Plate-reader, China) and platelet count using a Haematology Analyzer (Mindray BC5300, China).
Results: There were 28 males and 18 females. Twenty (43.5%) of the 46 children with NS were in remission, 19 (41.3%) were in relapse and 7 (15.2%) had new disease.
The median fibrinogen levels in NS and controls group were 2.9g/L with IQR 1.1 to 7.2g/L and 1.4 to 4.5g/L respectively. The median fibrinogen levels were 4.9, 4.1, 2.3 and 3.0g/L in new disease, relapse, remission and controls respectively Sixteen (35%) children with NS had hyperfibrinogenaemia. The median fibrinogen levels of children in remission differed significantly with those of children in relapse (p = 0.001).
.The median AT levels were not significant, 142% and 131% in children with and without NS respectively, (p=0.134).
The median APTT was significantly different in NS and control group (p value = 0.02). The median PT levels also differed significantly (p = 0.004) and 90% of children with NS had INR within reference range. Thrombocytosis occurred in 15% of NS group. The median platelet count in those with new disease was significantly higher ((p = 0.01).
Conclusions: We observed haemostatic derangements in Nigerian children with NS especially involving Fibrinogen, APTT, PT, INR and Platelet count,warranting a high index of clinical suspicion and monitoring in children with NS. Antithrombin was unaffected.
To cite this abstract in AMA style:Odimegwu C, Nwagha T, Chinawa J, Ubesie A, Okafor H, Ikefuna A. Haemostatic Profile of Nigerian Children with Nephrotic Syndrome (NS) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/haemostatic-profile-of-nigerian-children-with-nephrotic-syndrome-ns/. Accessed October 1, 2023.
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