Abstract Number: PB0571
Meeting: ISTH 2021 Congress
Background: Frequency of HRU can be an indicator of disease burden.
Aims: Describe HRU in a cohort of adult PwHB with administrative claims for JD, regardless of cause.
Methods: PharMetrics Plus data from January 2010-April 2020 were used to study PwHB with no evidence of an inhibitor or non-mild liver disease. The cohort included males aged 19-64 years prescribed factor IX replacement during the study period and no evidence of bypassing agent use. JD was defined by relevant diagnosis/surgery codes in ≥1 inpatient claim, or in ≥2 outpatient claims ≥30 days apart. Severity of hemophilia was not available. HRU statistics account for differential follow-up.
Results: In total, 237 PwHB had HRU for JD. Mean age was 39.1 years (SD, 13.7). Of these, 167 (70.5%) had no coded diagnoses from 20 prespecified conditions of interest. Mild chronic liver disease, depression, and anxiety were reported in 8.4%, 7.6%, and 6.8%, respectively. The median follow-up from first JD diagnosis was 26.4 months (interquartile range, 13.1-48.7). Among the 237 PwHB, 10.7% had ≥1 joint surgery in the first 12 months following a JD diagnosis, with the highest joint surgery rate of 19.1% in those aged 31-44 years compared with 4.8% in those aged 19-30 years and 10.1% in those aged 45-64 years. For arthropathy-related inpatient admissions, the cumulative incidence risk at 12 months of follow-up was 8.0%. Mean length of stay was 4.6 days (SD, 4.1). The incidence rate of arthropathy-related emergency department visits was 24.3 per 100 person-years (95% CI, 20.9-28.3); of physical therapy visits was 59.4 per 100 person-years (95% CI, 53.8-65.4); and of pharmacy claims for pain relief medications was 133.4 per 100 person-years (95% CI, 125.0-142.3).
Conclusions: The observed rates of HRU in this cohort of PwHB and concurrent JD provides insight into the disease burden encountered for this population.
To cite this abstract in AMA style:Markson LE, Young L, Ban L, Chen Y, Zaha R, Fogarty PF. Health Care Resource Use (HRU) among Adult Persons with Hemophilia B (PwHB) and Concurrent Joint Disease (JD) in the United States [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/health-care-resource-use-hru-among-adult-persons-with-hemophilia-b-pwhb-and-concurrent-joint-disease-jd-in-the-united-states/. Accessed November 27, 2021.
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