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Health Care Resource Use (HRU) among Adult Persons with Hemophilia B (PwHB) and Concurrent Joint Disease (JD) in the United States

L.E. Markson1, L. Young2, L. Ban3, Y. Chen1, R. Zaha4, P.F. Fogarty1

1Pfizer Inc., Collegeville, United States, 2Pfizer Ltd, Walton Oaks, United Kingdom, 3PPD Ltd, Beijing, China, 4Evidera, Bethesda, United States

Abstract Number: PB0571

Meeting: ISTH 2021 Congress

Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical

Background: Frequency of HRU can be an indicator of disease burden.

Aims: Describe HRU in a cohort of adult PwHB with administrative claims for JD, regardless of cause.

Methods: PharMetrics Plus data from January 2010-April 2020 were used to study PwHB with no evidence of an inhibitor or non-mild liver disease. The cohort included males aged 19-64 years prescribed factor IX replacement during the study period and no evidence of bypassing agent use. JD was defined by relevant diagnosis/surgery codes in ≥1 inpatient claim, or in ≥2 outpatient claims ≥30 days apart. Severity of hemophilia was not available. HRU statistics account for differential follow-up.

Results: In total, 237 PwHB had HRU for JD. Mean age was 39.1 years (SD, 13.7). Of these, 167 (70.5%) had no coded diagnoses from 20 prespecified conditions of interest. Mild chronic liver disease, depression, and anxiety were reported in 8.4%, 7.6%, and 6.8%, respectively. The median follow-up from first JD diagnosis was 26.4 months (interquartile range, 13.1-48.7). Among the 237 PwHB, 10.7% had ≥1 joint surgery in the first 12 months following a JD diagnosis, with the highest joint surgery rate of 19.1% in those aged 31-44 years compared with 4.8% in those aged 19-30 years and 10.1% in those aged 45-64 years. For arthropathy-related inpatient admissions, the cumulative incidence risk at 12 months of follow-up was 8.0%. Mean length of stay was 4.6 days (SD, 4.1). The incidence rate of arthropathy-related emergency department visits was 24.3 per 100 person-years (95% CI, 20.9-28.3); of physical therapy visits was 59.4 per 100 person-years (95% CI, 53.8-65.4); and of pharmacy claims for pain relief medications was 133.4 per 100 person-years (95% CI, 125.0-142.3).

Conclusions: The observed rates of HRU in this cohort of PwHB and concurrent JD provides insight into the disease burden encountered for this population.

To cite this abstract in AMA style:

Markson LE, Young L, Ban L, Chen Y, Zaha R, Fogarty PF. Health Care Resource Use (HRU) among Adult Persons with Hemophilia B (PwHB) and Concurrent Joint Disease (JD) in the United States [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/health-care-resource-use-hru-among-adult-persons-with-hemophilia-b-pwhb-and-concurrent-joint-disease-jd-in-the-united-states/. Accessed September 29, 2023.

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