Abstract Number: PB0162
Meeting: ISTH 2021 Congress
Background: Impaired hemostasis is one of the main elements of COVID-19 associated pneumonia pathogenesis. Early detection and adequate correction of hemostasis impairments determine the pneumonia course and outcome.
Aims: The investigation objective was to study the changes of standard hemostasiological tests and thromboelastography indices in COVID-19 associated pneumonia patients.
Methods: We determined APTT, prothrombin time (PT), fibrinogen (F), D-dimers (D-d), antitrombin III (AT III), С-reactive protein (CRP), platelet count, and studied viscosity and elasticity of blood clots using kaolin-activated thromboelastography (TEG) in 49 patients aged 40-69 with clinical presentation of viral infection and bilateral multi-segmental pneumonia. According to CT, the severity of 100% cases corresponded to CT2-CT3. Acute respiratory failure (ARF) was diagnosed in 16 patients. A control group included 25 apparently healthy subjects.
Results: There were revealed a marked acute-phase reaction characterized by increased fibrinogen (5.44 [4.34; 7.0]) and CRP (34.5 [16.0; 108]) concentrations, high D-d concentration (819 [472; 1769]) indicating intravascular homeostasis activation, and PT prolongation, which are descriptive of protein synthesis hepatic function (12.8 [12.5; 13.5]). D-d concentration correlated with patient`s age (r=0.61; p<0.05) and comorbidity (r=0.58; p<0.05). We found neither the alterations in TEG findings, nor the association between TEG parameters characterizing blood clot density (МА and G) and a fibrinogen level; yet there was revealed the relationship of the characteristics and platelet count (r=0.61; p<0.05).
Conclusions: Patients with COVID-19 associated pneumonia present impaired hemostatic system of thrombogenic nature. Moreover, kaolin-activated thromboelastography appeared to be less informative, so further investigations are required to make an objective assessment of blood viscosity and elasticity.
To cite this abstract in AMA style:Presnyakova M, Galova E, Kostina O. Hemostasiological Blood Properties in Patients with COVID-19 Associated Viral Pneumonia [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/hemostasiological-blood-properties-in-patients-with-covid-19-associated-viral-pneumonia/. Accessed September 30, 2023.
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