Abstract Number: PB0272
Meeting: ISTH 2021 Congress
Background: Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in COVID-19 patients. Here, we review the current state of knowledge of COVID-19 and hemostasis.
Aims: Aim of our study was investigation of hemostasis in patients with post-COVID-19 syndrome (PCS).
Methods: Materials and methods: We studied 136 patients with PCS, 78 were men, 58 – women. Average age was 49,9±4,7 years. Control group included 20 healthy people. Patients were divided into 3 groups. In the 1st group were united 20 patients with chronic respiratory diseases (CRD) and chronic cardiovascular diseases (CCVD), in second group – 56 patients with different CRD, in third – 60 patients with CCVD. Fibrinogen concentration (F), D-dimer, activated partial thromboplastin time (APTT), and prothrombin index (P) with INR were studied in all patients and control group by standard methods.
Results: For the 1st and 3d groups was characteristic increased level of F, d-dimer and APTT, compared with healthy persons. In the 2d group F level was also increased comparing with control group. P and INR was similar to control group in all 3 groups, though in 1st and 2d groups tendency of P diminishing was revealed. F and d-dimer level was high, but different in all groups. In the 1st group F and d-dimer level was higher on 18,8%, than in the 3d group and higher on 14,5%, than in 2d one.
Conclusions: Hemostasis abnormalities revealed in the patients with comorbid diseases points to high risk of thromboembolic complications and underlines the necessity of monitoring coagulation tests for appropriate treatment.
To cite this abstract in AMA style:Noniashvili M, Saralidze T, Svanidze T, Kandashvili T, Mamatsashvili I. Hemostasis Abnormalities in Post-COVID-19 Syndrome [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/hemostasis-abnormalities-in-post-covid-19-syndrome/. Accessed November 27, 2021.
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