Abstract Number: PB0266
Meeting: ISTH 2021 Congress
Theme: COVID and Coagulation » COVID and Coagulation, Clinical
Background: Hemostasis disorders in COVID-19 have specific clinical and laboratory features that differ from the “classic” form of DIC.
Aims: To investigate the change in hemostasis indices in patients with severe course of COVID-19.
Methods: A prospective study of 122 patients (men 53%, women 47%) with a severe course of COVID-19 was carried out. The age was 59 ±12 years. The patients’ condition, assessed by the NEWS and SOFA severity score, was 4.5 ± 1.4 and 6.1 ± 1.3 points. The control group was consisted of 20 apparently healthy donors. The research was performed on the 1st and 7th days from the moment of admission to the hospital.
Results: There was a significant increase of D-dimer’s level in patients on the first day (1.17 (0.45-4.09) mg/l, p˂0.001) and on the 7th day (1.28 (0.46-3.23) mg/l, p˂0.001). FG level was also significantly high in patients on the 1st day of the study (4.93 (3.49-6.11) g/l, p˂0.001) and on day 7 (4.23 (3.15-5.68) g/l, p˂0.001). PT was significantly lower in patients with COVID-19 than in the control group on the 1st day (78.7 (68.0-91.0) %, p=0.0003) and remained within normal values on the 7th day. Platelet count was significantly lower in patients than in the control group on the 1st day (190 (127-266) 109/l, p=0.006) and remained within normal values on the 7 th day. We calculated the index according to the ISTH’s scoring scale and found that most patients with COVID-19 didn’t score points to diagnose DIC-syndrome (Fig. 1).
Figure 1. Scoring scale to confirm DIC in patients with COVID-19 who were being treated in N.V. Sklifosovsky Research Institute for Emergency Medicine.
Conclusions: According to our data, prolongation of prothrombin time, thrombocytopenia and hypofibrinogenemia, decrease of antithrombin III in patients with COVID-19 on the 1st day and 7th were rare. Most patients showed a significant increase of D-dimer, the rest of the hemostasis indices didn’t correspond to the DIC-syndrome.
To cite this abstract in AMA style:
Klychnikova E, Popugaev K, Tazina E, Petrikov S, Badygov S, Bulanov A. Hemostasis Disorder in COVID-19 Patients: Disseminated Intravascular Clotting (DIC)? [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/hemostasis-disorder-in-covid-19-patients-disseminated-intravascular-clotting-dic/. Accessed November 27, 2021.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/hemostasis-disorder-in-covid-19-patients-disseminated-intravascular-clotting-dic/