Background: Alzheimer´s disease (AD) is the most frequent cause of dementia. Several hypotheses aim to explain its pathophysiology, which is complex and multifactorial. Hemostatic alterations have been reported in the pathogenesis of AD.

Aims: To investigate possible hemostatic alterations in patients with AD compared to behavioral variant frontotemporal dementia (bvFTD), another important cause of cognitive decline, and in elderly individuals with no cognitive impairment.

Methods: A total of 92 subjects were enrolled and distributed into three groups: AD (n= 34); bvFTD (n= 29) and controls (n=29). Hemostatic alterations were investigated by thrombin generation assays using thrombomodulin (TM) to investigate the resistance to this natural anticoagulant, in addition to plasma levels of ADMA (dimethylassimetric arginine), von Willebrand Factor (FvW), TM and ADAMTS-13 measurements. The study received approval from the local Ethics Committee.

Results: Higher plasma levels of ADAMTS-13 were observed in patients with AD and bvDFT compared to controls, however, no difference was found between the two dementias. ADMA, FvW and TM plasma levels and thrombin generation parameters were not different among groups.

Conclusions: There was no difference in the hemostatic profile between patients with AD and bvFTD, and between them and the controls. However, the higher plasma levels of ADAMTS-13 in patients with AD and bvFTD compared to controls encourage further studies on the role of this enzyme in the pathophysiology of dementias.
Ackowledgement: We are very grateful to CAPES, FAPEMIG (APQ 00512-14) and CNPq (426933/2016-8).

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/hemostatic-profile-is-there-any-difference-between-alzheimers-disease-and-frontotemporal-dementia/