Abstract Number: PB0089
Meeting: ISTH 2020 Congress
Background: Arterial ischemic stroke (AIS) is the second most common cause of death in Tunisia in the last 15 years and whose etiological investigation is still challenging. Some recent reports have noticed a probable accountability of common prothrombotic risk factors in the AIS’s occurrence.
Aims: Our study was aimed to describe epidemiological and biological characteristics of AIS in a young Tunisian population.
Methods: This study was carried out in 253 adults younger than 55 years old who had presented an arterial ischemic stroke (AIS) and were referred to our laboratory from 2012 to 2018. Biological exploration included the PS, PC and APC resistance (APC-R) analysis by coagulometric methods (STACLOT® PROTEIN S ; STACLOT® PROTEIN C;STACLOT® APC-R diagnostica) and the AT analysis by a chromogenic method (STA-CHROM-AT diagnostica).
Results: The mean age of our patients was 38 ± 12 years old and the sex ratio was about 1.Our study revealed the presence of 35 cases (13%) congenital thrombophilic markers as follows: PS deficiency was detected in three patients/206 (1.5%), PC defect noticed in two cases/209 (1%), ATIII deficiency detected in three patients/231 (1.3%) and the APC-R found in 27 cases/225 (12%). In addition, combined disorders were noticed in 0.8%: PS defect and APC-R; AT and APC-R deficiencies.
Conclusions: According to some recent research papers, we consider that thrombophilia in AIS is rather frequent in the South of Tunisia. The most prominent effect has been awarded to the APC-R which was slightly increased in our study.Its high rate could be explained by the geographical origin of patients and by the endogamy’s concept. Added to that, it is worth mentioning that combined defects do exist in our series. Then, it would be necessary to enlarge the number of samples to understand the thrombophilic characteristics of young Tunisian adults who suffered from AIS to decide the anticoagulant therapy.
To cite this abstract in AMA style:
Kallel A, Megdich F, Mbarek L, Krichen I, Ben Ayed I, Dammak M, Mhiri C, Kallel C. Hereditary Thrombophilia in Arterial Ischemic Stroke: A Study from the South of Tunisia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/hereditary-thrombophilia-in-arterial-ischemic-stroke-a-study-from-the-south-of-tunisia/. Accessed September 22, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/hereditary-thrombophilia-in-arterial-ischemic-stroke-a-study-from-the-south-of-tunisia/