Background: Many factors contribute for in vitro fertilization (IVF) failure, and hereditary thrombophilia as hypercoagulable condition has been mentioned as one of them. There are limited data on the association between thrombophilia with IVF failure in Macedonian population. 

Aims: The aim of the study was to examine the representation of thrombophilic mutations in Macedonian women with IVF failure and healthy controls.

Methods: In this case-control study we evaluated 70 women, divided in two groups. The case group included 34 women with history of women with three or more failed cycles of IVF. The control group included 36 women, age matched, who gave birth to at least one healthy baby without obstetric complications.  All women included in the study have signed the informed consent approved by the Ethical Committee of the Medical faculty in Skopje. Presence of gene mutations for prothrombin G20210A, factor V Leiden G1691A (FVL) and methylentetrahydrofolate reductase C677T (MTHFR) was examined in both groups.

Results: Prothrombin G20210A heterozygous was found in 5.9% of the case group vs. 5.5% in the control group; FVL heterozygous was found in 20.6% of the case group vs. 2.8% in the control group with a significant statistical difference (p=0.0194); MTHFR homozygous was found in 20.6% of the case group vs. 5.5% in the control group. Combined thrombophilic mutations were present in 17.6% in the case group and 5.6% in the control group.

Conclusions: Hereditary thrombophilia is more prevalent in women with IVF failure than the control group. The presence of at least one thrombophilic mutation especially FVL heterozygous and MTHFR homozygous may have significant role in IVF failure.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/hereditary-thrombophilia-in-macedonian-women-with-in-vitro-fertilization-failure/