Abstract Number: PB2529
Meeting: ISTH 2020 Congress
Background: Recent published studies revealed the possible role played by the Nucleosomes circulating complexes comprising DNA tightly wrapped around a core of Histone proteins (H2A, H2B, H3, H4) in pregnancy complications.
Aims: The purpose of our study was to evaluate global coagulation in a group of 89 women with obstetrical complications encompassing Preeclampsia (PE), Pregnancy-induced Hypertension (PIH), Small for Gestational Age (SGA), Preterm Labor (PTL), Placental Abruption (AP) and Intra Uterine Fetal Death (IUFD).
Methods: 89 consecutive referrals of pregnant women with one of the following diagnoses of obstetrical complications PE, PIH, SGA, PTL, AP, IUFD were enrolled. During the same period of time, we also enrolled 89 healthy pregnant women matched with cases for age (± 1 year) and gestational age (±2 weeks). We collected a blood sample from each patient to assess the TG global coagulative profile by CAT method and to evaluate H4 Histones plasma levels with ELISA.
Results: Among the 89 cases (mean age 33 ± 5 yrs), n. 12 (13,5%) had a diagnosis of PE, n. 14 (15,7%) PIH, n. 9 (10,1%) SGA, n. 14(15,7%) PTL, n. 23(25,8%) AP and n. 17 (19,2%) IUFD. Overall, patients with obstetrical complications showed significantly higher average Endogenous Thrombin Potential (ETP) values (1690,2±365,1 nM*min) compared to the control population (1451,3 ± 210,7 nM*min, p< 0,0001). The average levels of H4 Histone in women with obstetrical complications were significantly higher (152,6 ±100,1 AU) vs. heathy controls (110,7±54,3 AU, p=0,0007).
Conclusions: In conclusion, our study highlights a hypercoagulability state in women with obstetrical complications compared to the control population, characterized by a significant increase of ETP values and of H4 Histone plasma levels. Larger prospective studies are required to confirm these findings.
To cite this abstract in AMA style:Spiezia L, Calzamatta G, Campello E, Bulato C, Gavasso S, Gervasi MT, Romero R, Simioni P. Histone H4 Plasma Levels in Women with Pregnancy Complications [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/histone-h4-plasma-levels-in-women-with-pregnancy-complications/. Accessed November 28, 2021.
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