Abstract Number: PO118
Meeting: ISTH 2021 Congress
Theme: Arterial Thromboembolism » Cardiovascular Risk Factors
Background: The impact of lifestyle on blood homocysteine levels is undeniable. The role of hyperhomocysteinemia in the development of vascular pathology is also well known. The climatic and geographical features of human life in the Arctic region also leave their mark.
Aims: Determination of changes in blood homocysteine levels in athletes living in the Arctic region of the Russian.
Methods: The study included a survey of 98 athletes involved in various sports living in the Arctic region of the RF. The median age was 19.5 (16; 25) years. Determination of blood serum homocysteine level was done by enzyme immunoassay. Polymorphisms of three folate cycle genes were studied: MTHFR 677C>T polymorphism, MTHFR polymorphism (glu429ala); MTRR A66G polymorphism.
Results: Homocysteine levels were from 3.33 to 50.0 (Me=15.84) μmol/L. A weak correlation was found between the level of homocysteine and the gender of the athlete (r=0.037, p=0.774), the age of the athlete (r=0.222, p=0.081), the level of sportsmanship (r=0.079, p=0.540). The polymorphism MTHFR 677 C>T was found in 45% of cases (CI: 34-57%), homozygotes – 5% (CI: 1.5-12%) of alleles and heterozygotes – 40% (CI: 30-52%). MTHFR (glu429ala) polymorphism was found in 48% (CI: 36-59%), the homozygous allele A1298C was in 3.6% (CI: 0.8-10.3%). Heterozygotes – in 44% of cases (CI: 33-55%). The genetic marker MTRR A66G had a frequency of 76% (CI: 65-84%); homozygous variant in 23% (CI: 15-34%), heterozygous in 52% (CI: 41-64%).
Conclusions: Demonstrated a mild to moderate degree of hyperhomocysteinemia. There were no differences in the level of homocysteine depending on the allelic variants of the folate cycle enzyme genes (p=0.395, p=0.987, p=0.852). Differences in blood homocysteine concentration in athletes with different alleles of the same gene of the folate cycle are insignificant. Which may indicate the influence of external factors on the high level of homocysteine in the blood.
To cite this abstract in AMA style:
Vorobyeva N, Malyshkina N. Homocysteine Exchange in Athletes in the Arctic Region [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/homocysteine-exchange-in-athletes-in-the-arctic-region/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/homocysteine-exchange-in-athletes-in-the-arctic-region/