Abstract Number: PB0004
Meeting: ISTH 2020 Congress
Background: Oxygen therapy (OT) has often been used for the treatment of patients with acute myocardial infarction (AMI). However, the evidence from randomized control trials (RCTs) on the use of OT in AMI is conflicting and many recent systematic reviews have explored to summarize the evidence.
Aims: To synthesize the evidence from systematic reviews assessing the benefit and harm associated with OT for the treatment of AMI.
Methods: We searched the PubMed, Embase, Cochrane, and Epistemonikos databases (for the last five years) for systematic reviews assessing OT for AMI patients. Reviews including ACS population were excluded; reviews specifically focusing on the AMI population were included. Two researchers independently performed the assessment for inclusion, quality assessment (AMSTAR), and data extraction.
The individual reviews constituted 4-8 RCTs, with total of nine unique RCTs included across the reviews, with a patient population ranged 871-7998. Included RCTs were published from 1976 to 2017. The majority of the reviews (5) were of medium to high quality. Across reviews, OT did not show improvement in key outcomes of all-cause mortality, recurrent ischemia/MI, and pain. In contrast, OT was associated with an increased rate of recurrent MI, longer average hospital length of stay, and a trend in increased mortality.
Conclusions: Evidence from the recent systematic reviews, and constituting primary studies, unanimously confirms the uncertainty around the perceived beneficial effect of OT while its harmful effect cannot be ruled out for the patients with AMI. The finding support retiring the use of OT in AMI population, particularly in normoxaemic AMI population, until a well-conducted, high-quality RCTs suggests otherwise.
To cite this abstract in AMA style:Singh A, Hussain S, Antony B. How Much Evidence Is Needed to Conclude against the Use of Oxygen Therapy in Acute Myocardial Infarction? [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/how-much-evidence-is-needed-to-conclude-against-the-use-of-oxygen-therapy-in-acute-myocardial-infarction/. Accessed June 22, 2021.
« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/how-much-evidence-is-needed-to-conclude-against-the-use-of-oxygen-therapy-in-acute-myocardial-infarction/